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MGF Igf-1-ec

IGF-1Ec, IGF-1Eb, Mechano-Growth Factor

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Active Not Recruiting OBSERVATIONAL NCT05651620

The CALERIE™ Legacy Study

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.

Detailed Description

The CALERIE Legacy Study is an observational follow-up study of participants from phase 2 the CALERIE trial, the first randomized controlled trial of calorie restriction (CR) in humans without obesity. The overarching goal of the CALERIE Legacy Study is to examine whether two years of CR results in sustained improvements in the biological, phenotypic, and functional hallmarks of human aging 10 to 15 years after the structured intervention. Participants will complete clinical assessments, dietary recalls, and questionnaires, and laboratory evaluations will be performed on blood and urine samples. The study also includes an optional biospecimen banking component.

Primary Outcomes

Measure: Biological age - Klemera-Doubal Method

TimeFrame: 10-15 years post CALERIE trial

Description: Biological age will be quantified by the Klemera-Doubal Method (KDM), an algorithm-based measure. Biological age is expressed in years.

Measure: Healthspan

TimeFrame: 10-15 years post CALERIE trial

Description: Healthspan will be assessed by sex-specific metabolic syndrome score (MSS). MSS was developed using mean blood pressure (MBP; = \[2 × diastolic blood pressure + systolic blood pressure\]/3), high density lipoprotein cholesterol (HDL), triglycerides (TG), waist circumference (WC), and fasting blood glucose (FBG): Women: MSS = \[45-HDL\]/SDHDLW+ \[TG-150\]/SDTG + \[WC-88\]/SDWCW + \[FBG-100\]/SDFBG + \[mean BP-100\]/SDMBP Men: MSS = \[40-HDL\]/SDHDLW+ \[TG-150\]/SDTG + \[WC-102\]/SDWCW + \[FBG-100\]/SDFBG + \[mean BP-100\]/SDMBP This score does not have a unit.

Trial Information

NCT ID

NCT05651620

Status

Active Not Recruiting

Study Type

OBSERVATIONAL

Sponsor

Tufts University

Last Updated

December 15, 2025

Related Peptides

IGF-1 MGF Igf-1-ec