Optimization of Dielectric Material Improves Ionization Capability and Mass Range of Dielectric Barrier Discharge Ionization Mass Spectrometry.
Guan. Xiaokang X; Wei. Chencheng C; Yan. Xiaowen X; Zenobi. Renato R
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Nonapeptide-1
Melanostatine-5, White 05
A synthetic nonapeptide that inhibits melanin synthesis by antagonizing the MC1R receptor, used in cosmetics for skin lightening and reducing hyperpigmentation.
Molecular Profile
Formula
C61H87N15O9S
Mol. Weight
1206.5 g/mol
Sequence
Gly-Glu-Pro-Pro...
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Topical
0.0001-5% in formulations
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How It Works
How It Works: Nonapeptide-1 acts as a competitive antagonist to the melanocortin-1 receptor (MC1R), blocking α-MSH binding and thereby inhibiting melanin production in melanocytes.
- Competitively antagonizes α-MSH at MC1R, preventing receptor activation.
- Inhibits tyrosinase enzyme activity, reducing melanin synthesis.
- Helps in lightening skin and preventing hyperpigmentation by modulating pigmentation pathways.
Latest Clinical Trials
See All Clinical Trials
Completed
NA
NCT00982046
A Clinical Comparison of Three Contact Lens Care Systems and Their Effect on Contact Lenses
Alcon Research
INTERVENTIONAL
Updated Dec 15, 2025
Completed
NCT00105131
Genetic Characterization of Parkinson's Disease
National Institute of Neurological Disorders and Stroke (NINDS)
OBSERVATIONAL
Updated Dec 15, 2025
Completed
NCT00099307
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
OBSERVATIONAL
Updated Dec 15, 2025
Latest Studies
See All StudiesEnhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging.
Huang. Zeng-Jin ZJ; Zhou. Xin-Hui XH; Wen. Wei-Qiu WQ; Huang. Ze-Ting ZT; Xuan....
Scientists made a tiny particle that holds a green‑tea compound (EGCG) and attaches it to a short peptide (nonapeptide‑1). This combo protects EGCG from breaking down, lets it release slowly, blocks UV light, and helps reduce skin pigment and DNA damage caused by sun exposure, making it a potentially stronger anti‑aging skin treatment.
Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway.
Chen. Jiaoquan J; Li. Huaping H; Liang. Bihua B; Zhu. Huilan H
A lab study found that tea polyphenol extracts can lower UV‑induced skin darkening by cutting down melanin production and the activity of key pigment‑making proteins. The peptide nonapeptide‑1 was only used as a comparison and showed no clear benefit.