Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging.
Huang. Zeng-Jin ZJ; Zhou. Xin-Hui XH; Wen. Wei-Qiu WQ; Huang. Ze-Ting ZT; Xuan. Jie J; Gui. Ping P; Peng. Weihua W; Wang. Guanhai G
Key Findings
- EGCG loaded into nonapeptide‑1‑conjugated mesoporous silica nanoparticles (EGCG@NP‑MSN) showed much better stability and controlled release.
- Melanin inhibition was 5.22‑times higher and tyrosinase inhibition 1.57‑times higher than using free EGCG alone.
- The formulation reduced UV‑induced DNA damage in skin cells while keeping antioxidant activity.
Practical Outcomes
- For DIY biohackers, the study suggests that pairing EGCG with a peptide‑based nanoparticle carrier could dramatically boost skin‑brightening and anti‑aging effects, but making such nanoparticles requires specialized chemistry. Until commercial products adopt this tech, the main takeaway is that standard EGCG or green‑tea extracts may be less effective than a stabilized, controlled‑release version.
Summary
Scientists made a tiny particle that holds a green‑tea compound (EGCG) and attaches it to a short peptide (nonapeptide‑1). This combo protects EGCG from breaking down, lets it release slowly, blocks UV light, and helps reduce skin pigment and DNA damage caused by sun exposure, making it a potentially stronger anti‑aging skin treatment.
Abstract
Epigallocatechin-3-gallate (EGCG), a catechin present in green tea, has been studied extensively for its potential as a cosmetic ingredient due to its various biological properties. However, the low stability and bioavailability of EGCG have hindered its effective utilization in cosmetic applications. This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG. MSNs can regulate the EGCG release and provide ultraviolet light (UV) protection to possess excellent photostability. Nonapeptide-1 exhibits melanin transfer interference properties and reduces the melanin content in treated skin areas. In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation. The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG. The utilization of this innovative platform offers the potential for enhanced stability, controlled release, and targeted action of EGCG, thereby providing significant advantages for skin application.This delivery system combines the advantages of antioxidant, anti-aging, and anti-UV radiation properties, paving the way for the cosmetics development with improved efficacy and better performance in promoting skin health and appearance.
Study Information
pubmed
2024
2024-09-12T00:00:00.000Z
10.1016/j.ijpharm.2024.124690
7
50