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Nonapeptide-1

Melanostatine-5, White 05

Quick Stats
Studies 4
Trials 100
Completed NA INTERVENTIONAL NCT05578079

The Effectiveness of Music on Pain During Heel Blood Collection in Premature Infants

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Premature babies receiving treatment and care in the Neonatal Intensive Care Unit (NICU) are exposed to various painful procedures. Repetitive and untreated painful procedures have a negative impact on the physiological, cognitive and behavioral development of the baby. Various approaches such as white noise, music, lullaby, kangaroo care, breastfeeding, swaddling, massage, and therapeutic positioning are used to reduce the painful processes that newborns are exposed to in the NICU.

Detailed Description

Premature babies receiving treatment and care in the Neonatal Intensive Care Unit (NICU) are exposed to various painful procedures. Repetitive and untreated painful procedures have a negative impact on the physiological, cognitive and behavioral development of the baby. Various approaches such as white noise, music, lullaby, kangaroo care, breastfeeding, swaddling, massage, and therapeutic positioning are used to reduce the painful processes that newborns are exposed to in the NICU.

Interventions

Name: Music
Type: OTHER
Description: Intervention-1 group will listen to the classical music that the "Arts of Fugue" by Bach.
Name: Music
Type: OTHER
Description: Intervention-2 group will listen to lullaby.

Primary Outcomes

Measure: Baby's heart rate
TimeFrame: 2 minutes before collecting heel blood
Description: The baby's pulse rate will be measured.
Measure: Baby's heart rate
TimeFrame: During heel blood collection
Description: The baby's pulse rate will be measured.
Measure: Baby's heart rate
TimeFrame: 2 minutes after collecting heel blood
Description: The baby's pulse rate will be measured.
Measure: Baby's respiratory rate
TimeFrame: 2 minutes before collecting heel blood
Description: The baby's respiratory rate will be measured.
Measure: Baby's respiratory rate
TimeFrame: During heel blood collection
Description: The baby's respiratory rate will be measured.
Measure: Baby's respiratory rate
TimeFrame: 2 minutes after collecting heel blood
Description: The baby's respiratory rate will be measured.
Measure: Baby's oxygen saturation
TimeFrame: 2 minutes before collecting heel blood
Description: The baby's oxygen saturation will be measured.
Measure: Baby's oxygen saturation
TimeFrame: During heel blood collection
Description: The baby's oxygen saturation will be measured.
Measure: Baby's oxygen saturation
TimeFrame: 2 minutes after collecting heel blood
Description: The baby's oxygen saturation will be measured.
Measure: Premature Infant Pain Profile (PIPP)
TimeFrame: 2 minutes before collecting heel blood
Description: PIPP scores will be evaluated separately by two experts in the field.
Measure: Premature Infant Pain Profile (PIPP)
TimeFrame: During heel blood collection
Description: PIPP scores will be evaluated separately by two experts in the field.
Measure: Premature Infant Pain Profile (PIPP)
TimeFrame: 2 minutes after collecting heel blood
Description: PIPP scores will be evaluated separately by two experts in the field.

Trial Information

NCT ID

NCT05578079

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Izmir Katip Celebi University

Last Updated

December 15, 2025