Palmitoyl-tetrapeptide-7

Rigin, Pal-GQPR, Palmitoyl-Gly-Gln-Pro-Arg

A synthetic palmitoylated tetrapeptide used in cosmetics to suppress inflammation, stimulate collagen production, and enhance skin repair for anti-aging benefits.

Quick Stats

Studies 3

Trials 2

Formula C₃₄H₆₂N₈O₇

Overview Studies 3 Clinical Trials 2

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Utility 2

pubmed Mar 27, 2015

Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.

Mondon. Philippe P; Hillion. Mélanie M; Peschard. Olivier O; Andre. Nada N; Marchand. Thibault...

The study shows that a skin‑care blend containing palmitoyl tetrapeptide‑7 (along with another peptide) can improve the structure of the skin’s extracellular matrix and make the skin‑dermis junction smoother in older skin. The researchers used advanced imaging tools to see these changes, and they found that the peptide blend reduced a low‑echogenic band under the skin, which is a sign of healthier tissue.

Utility 2

pubmed Feb 27, 2025

Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing.

Xing. Cencan C; Hou. Liangxuan L; Sun. Chunbin C; Chen. Hongyu H; Li. Yingxian Y; Li. Luping L; Wu....

Scientists made a gel that mixes a skin‑friendly peptide (Pal‑7) with chitosan and stem cells from baby teeth. When they put this gel on wounds in diabetic mice, the cuts healed faster, with less inflammation and more new blood vessels.

Utility 2

pubmed Jul 21, 2021

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Resende. Diana I S P DISP; Ferreira. Marta Salvador MS; Sousa-Lobo. José Manuel JM; Sousa. Em&#...

The study looked at 88 facial products for sensitive skin and found that only about 17% contain peptides, including palmitoyl‑tetrapeptide‑7. There’s very little solid clinical proof that these peptides help sensitive skin – most of the data comes from patents and company brochures, and only one small trial actually tested people with sensitive skin.