Pinealon

EDR peptide, Glu-Asp-Arg tripeptide

A synthetic tripeptide that provides neuroprotection by modulating gene expression, reducing oxidative stress, and supporting cognitive function in the brain.

Molecular Profile

Formula C₁₅H₂₆N₆O₈

Mol. Weight 418.4 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 200-500 mcg	200-500 mcg	High (90%)	SUB
Intranasal 100-300 mcg	100-300 mcg	Moderate (30%)	INT
Intravenous (IV, animal studies) 10-100 mcg/kg	10-100 mcg/kg	Complete (100%)	INT

How It Works

How It Works: Pinealon acts as a bioregulator that penetrates the blood-brain barrier to influence gene expression and protein synthesis in neural tissues, promoting neuroprotection and cognitive enhancement.

Activates gene expression and synthesis of proteins involved in cell differentiation and survival.
Suppresses reactive oxygen species (ROS) accumulation and oxidative stress.
Enhances melatonin production and protects against neurodegeneration.

Pairs Well With

Latest Clinical Trials

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Completed EARLY PHASE1 NCT00848302

Endothelial Function in Human Arteries

The Cleveland Clinic

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 2

pubmed Jun 8, 2021

Optimization of Jiuzao protein hydrolysis conditions and antioxidant activity in vivo of Jiuzao tetrapeptide Asp-Arg-Glu-Leu by elevating the Nrf2/Keap1-p38/PI3K-MafK signaling pathway.

Jiang. Yunsong Y; Wang. Rui R; Yin. Zhongtian Z; Sun. Jinyuan J; Wang. Bowen B;...

Researchers found that a tiny protein piece called DREL, taken from a by‑product of Chinese liquor making, can boost antioxidant defenses and lower inflammation in rats by turning on the Nrf2 pathway. They also showed it can be added to the liquor without changing its flavor, suggesting it could be mixed into foods or drinks. However, the work is still in animals, with no human dosing or safety data yet.

pubmed Dec 31, 2020

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

Khavinson. Vladimir V; Linkova. Natalia N; Kozhevnikova. Ekaterina E; Trofimova....

Error: Timeout.

Utility 1

pubmed Feb 22, 2019

Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction.

Silanteva. Irina A IA; Komolkin. Andrei V AV; Morozova. Ekaterina A EA; Vorontso...

Scientists showed that the tiny peptide Glu-Asp-Arg can slip into the DNA’s major groove and touch specific parts of guanine, and that magnesium ions make this binding easier by shielding DNA’s negative charge. The work is purely mechanistic and doesn’t tell us how to use the peptide for health.

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