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EDR peptide, Glu-Asp-Arg tripeptide
A synthetic tripeptide that provides neuroprotection by modulating gene expression, reducing oxidative stress, and supporting cognitive function in the brain.
Kozina. L S LS
The study found that the short peptide pinealon (made of three amino acids) helped protect brain cells from low‑oxygen stress in animal experiments, working mainly by boosting the body's own antioxidant enzymes and possibly reducing harmful glutamate activity. It was the most effective of several similar peptides tested.
Umnov. R S RS; Lin'kova. N S NS; Khavinson. V Kh VKh
The paper reviews how certain brain‑protecting peptides, including pinealon, work and what has been seen when they are given to older adults. It compares short peptides like pinealon with larger protein mixes, and explains the cellular pathways they affect.
Myakotnykh. V S VS; Torgashov. M N MN; Egorin. K V KV; Meshchaninov. V N VN; Gavrilov. V I VI; Borov...
A small study of 110 people compared several anti‑aging tricks. The researchers found that taking two specific oligo‑peptide mixes – one of them called Pinealon – together gave the biggest drop in biological‑age markers, and that these peptide drinks were among the safest options tested.
Mendzheritsky. A M AM; Karantysh. G V GV; Ryzhak. G A GA; Prokofiev. V N VN
In old rats, two brain‑targeting peptides, Cortexin and Pinealon, helped protect the brain during low‑oxygen and mild‑cold stress. Cortexin was better at reducing harmful free radicals and cell‑death signals, while both peptides boosted stress‑related chemicals that might support brain health.
Bashkireva. A S AS; Artamonova. V G VG
A study on 150 truck drivers versus 150 metal workers found that drivers had more anxiety, depression, and borderline mental issues, likely due to long hours and road stress. Giving them a mix of special peptides, including pinealon, improved their mood, stress resistance, and reduced mental‑health problems. The best results came when pinealon was combined with another peptide, but the exact doses weren’t reported.
Meshchaninov. V N VN; Tkachenko. E L EL; Zharkov. S V SV; Gavrilov. I V IV; Katyreva. Iu E IuE
A small study on 32 people with multiple health issues found that the synthetic peptide Pinealon (and a similar peptide Vesugen) seemed to boost muscle‑building activity and improve brain function, which the researchers say could slow some signs of aging. However, the same study also saw signs that Pinealon might increase oxidative stress and lower certain blood stem cells, and it didn’t affect DNA packaging, which they called safe but still needs more research.
Jiang. Yunsong Y; Wang. Rui R; Yin. Zhongtian Z; Sun. Jinyuan J; Wang. Bowen B; Zhao. Dongrui D; Zen...
Researchers found that a tiny protein piece called DREL, taken from a by‑product of Chinese liquor making, can boost antioxidant defenses and lower inflammation in rats by turning on the Nrf2 pathway. They also showed it can be added to the liquor without changing its flavor, suggesting it could be mixed into foods or drinks. However, the work is still in animals, with no human dosing or safety data yet.
Kozina. L S LS; Arutiunian. A V AV; Stvolinskiĭ. S L SL; Khavinson. V Kh VKh
The study looked at tiny proteins called pinealon, vesugen, vilon and epitalon in test‑tube experiments. They didn’t act as direct antioxidants, but they could slow down fat damage in human lipoproteins, make red blood cells tougher, and seem to protect brain cells from dying, possibly by influencing cell death pathways.
Mendzheritskiĭ. A M AM; Karantysh. G V GV; Ryzhak. G A GA; Dem'ianenko. S V SV
In old rats exposed to sudden low‑oxygen conditions, the peptide Pinealon (a short chain of three amino acids) seemed to help keep brain cell death low and bring inflammation markers back toward normal levels, while another peptide, Cortexin, reduced cell‑death activity but left inflammation high. The work is purely in animals and under a very specific stress model, so it’s not ready for direct human use.
Nazimko. V A VA; Morgul'. E V EV; Petrova. O A OA; Sheĭkhova. R G RG; Kozina. L S LS; Savenko....
A short two‑week study on train‑crew workers found that taking Pinealon (100 µg twice a day) seemed to improve some measures of biological age and how well they adapted to work stress, suggesting the peptide might help maintain performance in demanding jobs.
Voicekhovskaya. M A MA; Chalisova. N I NI; Kontsevaya. E A EA; Ryzhak. G A GA
In rats, a synthetic version of the pinealon tripeptide (Glu‑Asp‑Ala) helped skin cells grow faster in young animals, but it didn’t have the same effect in older rats. Another peptide (Lys‑Glu‑Asp) worked better in old skin. The boost in cell growth seemed to come from less cell death, not just more cell division.
Mendzheritski. A M AM; Karantysh. G V GV; Abramchuk. V A VA; Ryzhak. G A GA
In a rat study, the peptide pinealon helped both young and old animals learn a maze better than another peptide called cortexin. The researchers also saw changes in a brain protein called caspase-3, which they think might be linked to learning ability.
Arutjunyan. Alexander A; Kozina. Lyudmila L; Stvolinskiy. Sergey S; Bulygina. Yelena Y; Mashkina. An...
In a rat study, giving the tiny peptide pinealon (Glu-Asp-Arg) to pregnant mothers that were fed a lot of methionine (which raises homocysteine levels) helped their babies perform better on learning tests and protected brain cells from oxidative damage.
Khavinson. V V; Ribakova. Y Y; Kulebiakin. K K; Vladychenskaya. E E; Kozina. L L; Arutjunyan. A A; B...
The lab study shows that the synthetic peptide pinealon can lower harmful oxidative molecules and protect cells from dying in test‑tube experiments, and it also seems to influence cell growth signals, hinting it might do more than just act as an antioxidant.
Khavinson. V Kh VKh; Lin'kova. N S NS; Tarnovskaya. S I SI; Umnov. R S RS; Elashkina. E V EV; Durnov...
A lab study found that the short peptide pinealon (Glu-Asp-Arg) and a similar peptide can raise serotonin‑making enzyme levels in aging brain cells, likely by binding to a specific DNA segment. This hints they might help protect brain function as we age, but the work was done only in cell cultures, not people.
Mendzheritskiĭ. A M AM; Karantysh. G V GV; Ivonina. K O KO
In old rats that had their carotid arteries blocked, giving the short peptide Pinealon before the blockage helped more animals survive, but it also made them less motivated and slower in some motor tasks. The peptide slightly increased a brain enzyme linked to cell death (caspase‑3). A similar peptide, Cortexin, only increased the time the rats spent in a dreaming‑like state.
Silanteva. Irina A IA; Komolkin. Andrei V AV; Morozova. Ekaterina A EA; Vorontsov-Velyaminov. Pavel...
Scientists showed that the tiny peptide Glu-Asp-Arg can slip into the DNA’s major groove and touch specific parts of guanine, and that magnesium ions make this binding easier by shielding DNA’s negative charge. The work is purely mechanistic and doesn’t tell us how to use the peptide for health.
Bashkireva. A S AS; Kachan. E Yu EY
The study looked at whether taking a mix of small anti‑aging peptides can help people who work in tough, hazardous jobs keep their ability to work and stay healthy. It found that adding these peptides to a preventive nutrition plan seemed to improve a work‑ability score, suggesting they might boost the body’s adaptive resources. However, the paper gives no details on which peptides, how much to take, or how to use them in everyday life.
Khavinson. Vladimir V; Linkova. Natalia N; Kozhevnikova. Ekaterina E; Trofimova. Svetlana S
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