[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Mendzheritsky. A M AM; Karantysh. G V GV; Ryzhak. G A GA; Prokofiev. V N VN
Key Findings
- Cortexin reduced free‑radical damage and caspase‑3 activity more than Pinealon in aged rat brains
- Both peptides increased adrenergic mediators during acute hypoxia
- Both peptides raised serotonin levels in the cortex during mild hypothermia
Practical Outcomes
- The study suggests these peptides could have neuro‑protective or anti‑aging effects, but it’s only in rats under extreme conditions. Until human trials are done, there’s no clear dosage or protocol for biohackers to apply safely.
Summary
In old rats, two brain‑targeting peptides, Cortexin and Pinealon, helped protect the brain during low‑oxygen and mild‑cold stress. Cortexin was better at reducing harmful free radicals and cell‑death signals, while both peptides boosted stress‑related chemicals that might support brain health.
Abstract
The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have been identified. Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon. Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects.
Study Information
pubmed
2015