[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Mendzheritskiĭ. A M AM; Karantysh. G V GV; Ryzhak. G A GA; Dem'ianenko. S V SV
Key Findings
- Pinealon reduced caspase‑3 activity (a marker of programmed cell death) in the brains of hypoxia‑stressed old rats.
- Pinealon lowered serum interleukin‑6 and tumor necrosis factor levels toward baseline, suggesting anti‑inflammatory effects.
- Cortexin also lowered brain caspase‑3 activity but did not reduce, and even maintained, high IL‑6 levels.
Practical Outcomes
- For biohackers, the study hints that Pinealon might have neuroprotective and anti‑inflammatory properties under acute oxygen‑deficit stress, but there’s no human data, dosing guidance, or safety profile. Until more translational research is done, it’s not a protocol you can reliably apply, though it may warrant monitoring as future human trials emerge.
Summary
In old rats exposed to sudden low‑oxygen conditions, the peptide Pinealon (a short chain of three amino acids) seemed to help keep brain cell death low and bring inflammation markers back toward normal levels, while another peptide, Cortexin, reduced cell‑death activity but left inflammation high. The work is purely in animals and under a very specific stress model, so it’s not ready for direct human use.
Abstract
While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.
Study Information
pubmed
2014