[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].
Mendzheritski. A M AM; Karantysh. G V GV; Abramchuk. V A VA; Ryzhak. G A GA
Key Findings
- Pinealon improved maze learning performance in both young and aged rats.
- Caspase-3 activity and levels changed in the cortex and brainstem after peptide treatment.
- Cortexin did not boost learning as effectively as pinealon.
Practical Outcomes
- The results hint that pinealon could have cognitive‑enhancing effects, but the evidence is limited to rodents and does not provide dosage or safety data for humans. Biohackers should view this as an early, exploratory finding rather than a ready‑to‑use supplement protocol.
Summary
In a rat study, the peptide pinealon helped both young and old animals learn a maze better than another peptide called cortexin. The researchers also saw changes in a brain protein called caspase-3, which they think might be linked to learning ability.
Abstract
The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held. Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified. It is suggested that the functional state of caspase-3 in the brain is one of the reasons that determines the animals' ability to learn. Pinealon has prevalent positive effect on learning of both young and old animals in the Morris labyrinth compared to cortexin.
Study Information
pubmed
2013