[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].
Mendzheritskiĭ. A M AM; Karantysh. G V GV; Ivonina. K O KO
Key Findings
- Pinealon pretreatment improved survival after carotid artery occlusion in old rats.
- Pinealon reduced motivational and motor performance while increasing a sleep‑like behavior.
- Caspase‑3 activity rose modestly with Pinealon, indicating a possible increase in cell‑death signaling.
Practical Outcomes
- The results are specific to a rat model of severe brain blood flow loss and do not provide clear, safe guidance for human use. For biohackers, the study suggests that Pinealon may have mixed effects—potentially protective in extreme ischemic conditions but possibly impairing motivation and movement—so it is not ready for practical self‑experimentation.
Summary
In old rats that had their carotid arteries blocked, giving the short peptide Pinealon before the blockage helped more animals survive, but it also made them less motivated and slower in some motor tasks. The peptide slightly increased a brain enzyme linked to cell death (caspase‑3). A similar peptide, Cortexin, only increased the time the rats spent in a dreaming‑like state.
Abstract
The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted. It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries. Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced. The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time. At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.
Study Information
pubmed
2011