[Investigation of antihypoxic properties of short peptides].
Kozina. L S LS
Key Findings
- Pinealon showed the strongest antihypoxic effect among the peptides studied
- It increased neuronal resistance to hypoxia by stimulating internal antioxidant enzymes
- It may also limit excitotoxic damage from NMDA receptors
Practical Outcomes
- For biohackers, pinealon looks promising as a neuroprotective supplement for situations involving low oxygen, like altitude exposure or intense training, but there are no human dosage guidelines yet. More research is needed before it can be recommended as a standard protocol.
Summary
The study found that the short peptide pinealon (made of three amino acids) helped protect brain cells from low‑oxygen stress in animal experiments, working mainly by boosting the body's own antioxidant enzymes and possibly reducing harmful glutamate activity. It was the most effective of several similar peptides tested.
Abstract
The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia. Pinealon (Glu-Asp-Arg) has the most pronounced effect among them. The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature. It is based not so much on the inhibition of ROS increase in cells in response to stress as on stimulation of internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate.
Study Information
pubmed
2008