[Age-related characteristics of the thymus and adrenal cortex function in CBA mice immunized by T-dependent antigen].
Labunets'. I F IF
Key Findings
- Adult mice showed hormone changes that followed the phases of immunization, while old mice showed steady, monotonic changes.
- A correlation between thymic hormone levels and corticosterone was seen in both age groups.
- Giving thymalin to old mice did not improve thymic hormone or corticosterone dynamics after immunization.
Practical Outcomes
- Thymalin is unlikely to help older people improve immune or stress‑hormone responses based on this animal data. Biohackers should not count on thymalin for anti‑aging immune support and may focus on other interventions.
Summary
In a mouse study, giving the peptide thymalin didn’t boost the age‑related decline in a thymus‑related hormone or stress hormone after a vaccine‑type challenge, especially in older mice.
Abstract
The thymic serum factor (FTS) titer and corticosterone level in blood of adult and old CBA mice after immunization by T-dependent antigen was investigated. It has been revealed that in adult mice these indices influenced by phase changes in dynamics of immunization whereas in old mice fluctuations of FFS and corticosterone levels were monotonous. In both adult and old mice the correlation exists between thymic hormone and corticosterone. The increasing of thymic function by thymaline administration did not improve the dynamics of FTS titer and corticosterone level in immunized old mice.
Study Information
pubmed
2005