Menu
Submit Data
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Back to Studies

Thymalin

Thymulin, Thymic Factor, Serum Thymic Factor, Facteur Thymique Serique

Quick Stats
Studies 202
Trials 37
Overview Studies Clinical Trials
Score 2
1998 pubmed

[The effect of immunomodulators on the development of antibodies to the diphtheria antigen in mice vaccinated with the DTP adsorbed vaccine].

Chudnaia. L M LM; Frolov. A F AF; Oksiiuk. V G VG; Krasiuk. L S LS; Moroz. L V LV; Afanas'eva. S M SM

View Original Source

Key Findings

  • All tested immunomodulators raised anti‑diphtheria antibody titers compared to vaccine alone by day 120
  • Splenin and prodigiosan (subcutaneous) were the most effective in boosting antibodies
  • Dibasol and methyluracyl (oral) were especially promising when given before vaccination

Practical Outcomes

  • The results suggest that some immune‑modulating compounds might enhance vaccine responses, but the study is in mice and uses experimental drugs not approved for humans. Biohackers should treat this as preliminary evidence and wait for human trials before adding thymalin or similar agents to vaccination protocols.

Summary

In mice given a diphtheria vaccine, adding certain immune‑boosting substances (including thymalin) led to higher antibody levels than the vaccine alone, especially when given before vaccination. The strongest effects were seen with splenin and prodigiosan injected under the skin, and with dibasol and methyluracyl taken orally.

Abstract

An animal model for the study of the influence of immunomodulators on the development and preservation of postvaccinal antidiphtheria immunity was experimentally selected and the corresponding study was carried out. In this work the following immunomodulators were used: dibasol, prodigiosan, splenin, thymalin, reaferon, tactivin, methyluracyl. The study revealed that by day 120 of observation all immunomodulators stimulated the production of antibodies in higher titers than adsorbed DPT vaccine, introduced without immunomodulators. The most effective action was exhibited by splenin and prodigiosan (injected subcutaneously), dibasol and methyluracyl (administered orally). Two latter immunomodulators, if introduced prior to immunization, are the most promising preparations to be used in practical immunoprophylaxis.

Study Information

Provider

pubmed

Year

1998