[The effect of thymalin on the count of large granular lymphocytes in the peripheral blood of mice with leukemia P388].
Potapov. Iu N IuN; Khaleev. D V DV; Krutova. T V TV; Pashkova. V S VS
Key Findings
- Leukemia mice show a drop in large granular lymphocytes (natural killer cells).
- Multiple thymalin injections (0.66 mg/kg) maintained NK cell numbers at control levels.
- Thymalin did not extend the lifespan of the leukemia‑bearing mice.
Practical Outcomes
- Thymalin can preserve NK cell counts in a leukemia mouse model, but there’s no evidence it improves survival. For biohackers looking for longevity or performance gains, this study offers limited actionable insight and does not support using thymalin as a life‑extension supplement.
Summary
In mice with a type of leukemia, the natural killer immune cells drop, but giving them thymalin at a dose of 0.66 mg per kilogram kept those cells at normal levels. However, the treatment didn’t make the mice live longer.
Abstract
Effect of thymaline injections on peripheral blood natural killer cells in mice with p388 leukemia has been studied. The content of natural killers that have been identified as large granular lymphocytes decreased in blood of leukemia mice. Multiple thymaline injections (0.66 mg/kg) maintain the numbers of the lymphocytes at the level of control animals but did not increase the life span of leukemia mice.
Study Information
pubmed
1991