[Morphohistochemical appraisal of the efficacy of hyperbaric oxygenation, cytochrome c, and thymalin in the management of experimental gastric ulcers].
Uspenskiĭ. V M VM; Lotovin. A P AP; Vertelkin. V A VA; Saltykov. A A AA; Stefaniuk. N F NF
Key Findings
- Hyperbaric oxygen normalized xanthine oxidase activity and sped ulcer healing
- Cytochrome c had the same rapid normalizing effect
- Thymalin failed to normalize the enzyme and inflammation persisted
Practical Outcomes
- Thymalin showed no benefit for ulcer repair in this animal model, so it’s not a promising supplement for gut healing or ulcer prevention. Biohackers should prioritize other proven strategies like oxygen therapy or antioxidant support for gastric health.
Summary
In a rabbit study of stomach ulcers, hyperbaric oxygen and cytochrome c helped the ulcers heal quickly, but the peptide thymalin did not reduce a key inflammation enzyme and the ulcer tissue stayed inflamed.
Abstract
The authors studied the content of xanthine oxidase and the activity of the reparative process in the border of an acetate ulcer after Okabe in 48 rabbits before and during treatment by HBO, cytochrome c, and thymalin. In treatment by HBO and cytochrome c the activity of the enzyme was normalized rapidly, which coincided with cicatrization of the ulcer. In treatment with thymalin xanthinE oxidase activity was not normalized in this period and mucosal inflammation persisted in the zone of ulcer cicatrization.
Study Information
pubmed
1990