[Effect of thymus preparations and anti-tuberculosis agents on immunologic reactivity and the course of the tuberculosis process in experimental animals].
Demidov. S V SV; Miasnikov. V G VG; Chernushenko. E F EF; Osipova. L S LS
Key Findings
- Thymus peptides combined with TB drugs increased mouse lifespan
- Reduced spleen weight and lung density indices were observed
- T‑cell counts and proliferative activity rose, especially with thymogen
Practical Outcomes
- The data hint that thymalin could act as an immune‑supporting supplement, but the evidence is limited to diseased mice and doesn’t translate directly to healthy humans. Biohackers should view this as preliminary and wait for human studies before adding it to a longevity or performance regimen.
Summary
In a mouse study, adding thymus‑derived peptides like thymalin to standard tuberculosis drugs helped the animals live longer, reduced signs of disease in their organs, and boosted their T‑cell numbers and activity. The strongest effect was seen with thymogen, while vilosen was the weakest.
Abstract
The effects of thymogen, thymalin and vilosen in combination with antituberculous drugs (isoniazid, streptomycin, rifampicin) were studied on 240 CBA mice with experimental tuberculosis. Thymus preparations supplemented to the complex treatment of experimental tuberculosis significantly increased their lifespan, contributed to a decrease in the index of spleen weight lung density and significantly increased the count of T lymphocytes and their proliferative activity as compared to those on antituberculous drugs alone. Thymogen was found to be the most effective in the complex treatment of experimental tuberculosis, whereas vilosen was the least. Thymogen plus vilosen proved to be the most beneficial combination of drugs.
Study Information
pubmed
1991