[New approaches to the treatment of mycobacterioses of the lungs].
Aleksandrova. A E AE; Vasil'ev. A V AV; Lozovskaia. M E ME
Key Findings
- In mouse experiments, the regimen with kanamycin, ethambutol, thionamide, sulfadimethoxine and thymalin was the most effective among 32 tested combos.
- In a small human trial, adding thymalin to the antibiotic regimen increased bacillary excretion cessation from 30% to 82.6%.
- Thymalin was used as an adjunct peptide alongside standard antibiotics, not as a standalone therapy.
Practical Outcomes
- For biohackers dealing with mycobacterial lung infections, thymalin might be considered as a supportive add‑on to boost antibiotic effectiveness, but the evidence is preliminary and the study size is small. It isn’t a broad‑use supplement for longevity or performance, and any use should be under medical supervision.
Summary
A study tested many drug combos on mice with a lung infection and found the best mix included the peptide thymalin. When they tried this combo on 43 people with a tough lung infection, adding thymalin helped stop the bacteria being spit out in stool, raising success from about 30% to over 80%. The research suggests thymalin could boost antibiotic treatment for this specific infection, but the data are limited and it’s not a general health or longevity tip.
Abstract
The paper deals with improvement of pulmonary mycobacterioses treatment. In the preliminary experiments with the use of an experimental model, 32 regimens of M. avium mycobacteriosis treatment were tested on 872 white mice and the most efficient one was chosen, which comprised a combination of kanamycin-ethambutol-thionamide coupled with sulfadimethoxine and thymalin courses. The clinical course and results of treatment of 43 patients (23 of the main and 20 of the control group) with fibro-cavernous pulmonary mycobacteriosis were studied. Employment of the new treatment regimen significantly enhanced its efficiency--the incidence of bacillary excretion cessation increased from 30 to 82.6%.
Study Information
pubmed
1991