[Regulating properties of peptides of the thymus and bursa of Fabricius in immunodepression in birds].
Sukhinina. T L TL; Pridybaĭlo. N D ND; Morozov. V G VG; Khavinson. V Kh VKh
Key Findings
- Hydrocortisone sharply lowered DNA, RNA, and protein building activity in chicken thymus cells.
- Cyclophosphamide sharply lowered those activities in bursa cells.
- Thymalin and bursilin peptides boosted nucleic acid and protein synthesis in their respective organs despite the drug‑induced immune suppression.
Practical Outcomes
- The study hints that thymalin could support immune cell function when the system is stressed, but it’s an animal experiment with no human dosage or protocol guidance. Biohackers should view it as preliminary evidence, not a ready‑to‑use supplement plan.
Summary
In chickens that had their immune systems weakened with drugs, the peptide thymalin (from the thymus) and a similar peptide called bursilin (from the bursa) helped restore the cells' ability to make DNA, RNA, and proteins, especially in the organ where each peptide naturally comes from.
Abstract
The intensity of nucleic acids and protein synthesis in the cells of the thymus and the bursa of Fabricius was studied in chickens against the background of an immunodepression induced by administration of hydrocortisone and cyclophosphamide. It was found out that hydrocortisone causes in chicken a marked lowering of the intensity of inclusion of 3H-thymidine, 3H-uridine and 14C-glycine in thymic cells, and cyclophosphamide--in the cells of the bursa of Fabricius. Under the conditions of selective immunodepression the preparations on the basis of the peptides of the thymus (thymalin) and of the bursa of Fabricius (bursilin) regulate the processes of nucleic acids and protein synthesis chiefly in the cells of organs which produce them.
Study Information
pubmed
1990