[The effect of thymalin, dalargin and "Mucosalin" on the course of an experimental duodenal ulcer].
Lukash. N V NV; Polishchuk. T F TF
Key Findings
- All three regulatory peptides reduced duodenal ulcer severity in rats.
- Mucozaline (derived from pig stomach mucosa) provided the strongest protection.
- Thymalin showed a modest protective effect, less than dalargin and mucozaline.
Practical Outcomes
- For DIY health enthusiasts, this study suggests that thymalin may offer limited gut‑protective benefits, but the evidence is from an animal model and the effect size is modest. There is no clear dosage or protocol for humans, so thymalin should be considered experimental for ulcer protection. More human‑focused research would be needed before incorporating it into a longevity or performance regimen.
Summary
In a rat study, three peptides—thymalin, dalargin, and a pig‑stomach derived peptide called mucozaline—were tested for how well they protect the duodenum from ulcer damage. All three showed some protective effect, but mucozaline worked best, followed by dalargin, with thymalin being the least effective of the three.
Abstract
A peptide was obtained at our chair, from the mucous membrane of the stomach of the pig, using a method of acid extraction. The above peptide belongs to the group of cytomedines and is conventionally called "mucozaline". As many as 80 Wistar male rats were used in comparative evaluation of thymaline, dallargine and "mucozaline" for their effect on the course of duodenal ulcer in the rat. The results obtained showed that regulatory peptides play an important part in protection of the gastric and duodenal mucosa against the damaging factors. Of the above agents, it is "mucozaline" that has the greatest protective action, with dallargine and thymaline following it in the declining order.
Study Information
pubmed
1995