[Effect of thymic immunomodulators on the system of cyclic nucleotides of splenic T-lymphocytes after BCG vaccination].
Demidov. S V SV; Kostromin. A P AP; Chernyshenko. E F EF; Kuĭbeda. V V VV; Borovok. M I MI
Key Findings
- BCG vaccination raises activity of enzymes that make and break down cyclic nucleotides in T‑cells.
- Thymalin and thymogen increase cGMP synthesis, pushing the cAMP/cGMP ratio below normal levels.
- Vilosene, another thymic peptide, raises the cAMP/cGMP ratio during repeated BCG exposure.
Practical Outcomes
- Thymalin may have immune‑modulating effects by altering cGMP levels, but there’s no human data yet. For biohackers, it’s an interesting hint but not a ready‑to‑use protocol or dosage recommendation.
Summary
In guinea pigs, giving the peptide thymalin (along with thymogen) after a BCG vaccine boosted the production of a molecule called cGMP in T‑cells, which lowered the balance between cAMP and cGMP. This shift could affect how the immune system works, but the study was done in animals and didn’t test any human dosing or outcomes.
Abstract
The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination. It was shown that the disease was accompanied by increased activity of enzymes of anabolism and catabolism of cyclic nucleotides. Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level. At the same time vilosene increased this value in the process of a repeated BCG injection.
Study Information
pubmed
1990