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Thymalin

Thymulin, Thymic Factor, Serum Thymic Factor, Facteur Thymique Serique

Quick Stats
Studies 202
Trials 37
Overview Studies Clinical Trials
Score 2
1989 pubmed

[Inhibiting effect of thymogen on the development of tumors of the esophagus and forestomach induced by N-nitrososarcosine ethyl ester in rats].

Bespalov. V G VG; Troian. D N DN; Petrov. A S AS; Morozov. V G VG; Khavinson. V Kh VKh

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Key Findings

  • The carcinogen N‑nitrososarcosine ethyl ester caused many esophagus and forestomach tumors in all rats.
  • Thymogen reduced tumor incidence by about 12% and cut tumor multiplicity to roughly 60% of control levels.
  • The control peptide pulmolin did not affect tumor development.

Practical Outcomes

  • Thymogen shows a slight anti‑tumor effect in this animal model, suggesting it might have immune‑modulating properties, but there’s no human data, optimal dosing, or safety profile. Biohackers should view this as an early research signal rather than a ready‑to‑use protocol.

Summary

In a rat study, the synthetic peptide thymogen (similar to the natural peptide thymalin) was given after exposure to a cancer‑causing chemical and modestly lowered the number and size of esophagus and stomach tumors, while a related peptide had no effect. The effect was small and only shown in animals, so it isn’t ready for direct use by hobbyists.

Abstract

Immunostimulating synthetic peptide thymogen being an analog of the thymus polypeptide drug thymalin was studied for its effect on carcinogenesis of the esophagus and forestomach in male rats. Rats received N-nitrososarcosine ethyl ester (NSEE) per os in the daily dose of 100 mg/kg of body weight during 8 weeks. After cessation of the carcinogen administration rats were treated with thymogen (the daily dose of 10 micrograms per rat) or immune-inactive polypeptide drug pulmolin from the alveolar tissue of lung (the daily dose of 0.5 mg per rat) during the following 32 weeks. Animals were killed 40 weeks after the experiment beginning. NSEE induced the esophagus and forestomach tumours, mainly papillomas and rarely carcinomas, practically in all rats, more than 5 tumours per rat, on the average. Thymogen decreased the tumour incidence by 12% and made tumour multiplicity 1.7 times as low. Pulmolin did not influence development of these tumours.

Study Information

Provider

pubmed

Year

1989