In a lab model where blood‑forming cells were suppressed, the thymus‑derived peptide thymalin helped rebuild lymphocyte numbers, the bone‑marrow peptide haemalin boosted granulocyte production, and a mix called thymohaemin restored almost all blood and immune markers and improved overall resistance. The authors suggest these peptides could be tested in humans for helping recover a weakened blood‑forming system.

The effects of thymic peptide (thymalin), bone marrow peptide (haemalin) and a complex compound (thymohaemin) on the haematopoiesis and immunity were studied in the experimental model of the induced haematopoiesis depression. Lymphopoiesis stimulation in the bone marrow was provoked by thymalin and granulopoiesis stimulation by haemalin. Simultaneously the restoration of a number of both T- and B-lymphocytes in the thymus was observed. Thymohaemin resulted in the restoration of practically all peripheral blood and bone marrow indexes as well as content of T- and B-lymphocytes in both central and peripheral immunogenetic organs. Likewise the use of the thymus and bone marrow peptide preparations facilitated the restoration of non-specific resistance which was evaluated by means of an integral index--lysosomal cation test. The results allow us to recommend the above preparations for a clinical trial in the haematopoiesis depletion.