[Thymus and adaptive changes of bone marrow cell composition in animals of different age].
Labunets. I F IF; Rodnichenko. A E AE; Magdich. L V LV; Butenko. G M GM
Key Findings
- Thymalin increased levels of CD4+ cells and normalized corticosterone (stress hormone) in aged mice.
- The impact of thymalin on bone‑marrow precursor cells (CFC‑F and CFC‑GM) depended on the season in adult mice.
- In old mice, thymic supernatant (containing thymic serum factor) boosted CD4+ cell numbers in vitro.
Practical Outcomes
- For biohackers, the study suggests thymalin might support immune health and stress‑hormone balance in aging, but the findings are limited to mice and show seasonal variability. No human dosing or protocol is provided, so any use would be experimental and should be approached with caution.
Summary
In mice, giving the peptide thymalin (or a similar thymic factor) changed the number of certain bone‑marrow cells that help make immune cells, especially in older animals. The effect varied with the season, and thymalin helped restore normal patterns of CD4+ immune cells and stress hormone levels in old mice.
Abstract
The influence of thymus removal or administration of thymalin, thymic peptide factor, on number of cells-precursors for colonies of fibroblasts (CFC-F) and for granulocyte-macrophageal colonies (CFC-GM), CD(4+)-cells in bone marrow in CBA mice of different age in some seasons was investigated. It was shown that in adult mice the orientation of influence thymic activity modulation on amount of these types cells is dependent from seasons. It was shown the season possibility of direct effect of thymic stroma supernatant, in which was thymic serum factor (FTS), or the synthetic FTS on the amount of CFC-F and CFC-GM in bone marrow of adult mice; in old mice thymic supernatant increased in vitro the amount of CD(4+)-cells. FTS level in old mice increased after administration of thymalin, the rhythm of CD(4+)-cells number in bone marrow and of corticosterone serum content restored.
Study Information
pubmed
2011