[Geroprotective effect of thymalin and epithalamin].
Khavinson. V Kh VKh; Morozov. V G VG
Key Findings
- Thymalin and epithalamin improved cardiovascular, endocrine, immune, nervous system function and overall metabolism in older adults.
- Incidence of acute respiratory disease dropped 2‑2.4‑fold; heart disease, hypertension, osteoarthritis and osteoporosis were also reduced.
- Mortality decreased 2‑2.5‑fold with single‑peptide treatment and up to 4.1‑fold when both peptides were used together over several years.
Practical Outcomes
- For biohackers interested in longevity, the data suggest that regular, multi‑year supplementation with thymalin and/or epithalamin could meaningfully lower age‑related disease risk and extend healthy lifespan. However, the study does not detail dosing regimens, so any protocol would need to start with low, conservative doses and monitor health markers closely. Consider these peptides as experimental geroprotectors rather than proven, ready‑to‑use supplements.
Summary
A long‑term study in over 250 seniors found that taking the peptide drugs thymalin and epithalamin (either alone or together) for a few years lowered the rates of heart disease, high blood pressure, arthritis, osteoporosis and respiratory infections, and cut overall death rates by roughly half compared with untreated people.
Abstract
Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Research Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic and epiphyseal peptide bioregulators (Thymalin and Epithalamin, correspondingly) in 266 elderly and older persons during 6-8 years (the bioregulators were applied for the first 2-3 years of observation). The obtained results convincingly confirmed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of the cardiovascular, endocrine, immune, and nervous systems, homeostasis, and metabolism. The restoration of homeostasis in the patients was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence ischemic heart disease clinical manifestations, hypertension, deforming osteoarthrosis, and osteoporosis, as compared to the control group. Such a significant improvement in the somatic state of the peptide-treated patients corresponded to a decrease in their mortality rate during the observation period: 2.0-2.1-fold among the Thymalin-treated patients, 1.6-1.8-fold--in the Epithalamin-treated group, and 2.5-fold--in the patients treated with Thymalin combined with Epithalamin, as compared to the control group. A separate group of patients was treated with Thymalin combined with Epithalamin annually for 6 years. We registered a 4.1-fold mortality decrease in this group as compared to the control level. The results of our research confirmed the conclusion on the high geroprotective efficacy of Thymalin and Epithalamin and the expediency of their application in medicine and social care as the means of health maintenance and age-related pathology prevention in persons over 60 years old enabling the prolongation of the active period of their lives.
Study Information
pubmed
2002