[Lipid peroxidation and activity of antioxidant enzymes in thyroidectomized rats].
Hrinevych. Iu Ia IuIa; Bendiuh. H D HD; Bilokin'. Iu M IuM; Trembach. O M OM
Key Findings
- Three months after thyroid removal, rats lost a lot of body weight and showed changes in spleen size and cell count.
- Liver antioxidant enzyme levels stayed normal, while spleen catalase and superoxide dismutase activities rose markedly.
- Co‑administration of thyroxine and thymalin improved lipid peroxidation markers and limited pathological changes compared to thyroxine alone.
Practical Outcomes
- For biohackers, the study suggests thymalin might aid in managing oxidative stress when thyroid function is compromised, but the evidence is limited to a specific animal model. No human dosing or safety data are provided, so any trial would be experimental and should be approached with caution.
Summary
In rats that had their thyroid removed, giving them both thyroxine (a thyroid hormone) and the peptide thymalin helped keep oxidative damage in check and reduced some of the harmful changes that usually follow the surgery.
Abstract
The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.
Study Information
pubmed
2004