[Comparative study of immunomodulatory activity of peptides, tinrostim and thymalin].
Kuznetsova. T A TA; Besednova. N N NN; Zaporozhets. T S TS; Smolina. T P TP; Kazha. A K AK; Ivanushko. L A LA
Key Findings
- Tinrostim and thymalin both enhance humoral (antibody) and cellular immune responses in experimental animals.
- Both peptides increase phagocytic activity of neutrophils and raise cytokine production (TNF‑α, IL‑1, IL‑10) in peripheral blood cell cultures.
- A low dose of tinrostim (0.005 mg/kg) is as effective as a ten‑times higher dose (0.05 mg/kg) in mice.
Practical Outcomes
- For DIY health enthusiasts, the data suggest that low‑dose thymalin‑type peptides may be sufficient to achieve immune‑boosting effects, potentially lowering cost and side‑effect risk. However, the results are from animal studies, so human dosing and safety remain uncertain. Use caution and consider waiting for human trials before adopting a protocol.
Summary
The study shows that two peptide drugs, tinrostim (made from squid ganglia) and thymalin, boost immune function in animals. Both increase antibody production, T‑cell activity, and the ability of neutrophils to engulf pathogens, and they raise levels of both pro‑ and anti‑inflammatory signaling molecules. Notably, a ten‑fold lower dose of tinrostim works just as well as a higher dose.
Abstract
The immunomodulatory activity of peptide drugs i.e. tinrostim (dosage form) prepared of squid optical ganglia and pharmacopoeia thymain was studied. Tinrostim showed a stimulating effect on the humoral and cellular nimmune responses when administered parenterally in experimental animals, as well as on the phagocytic activity of neutrophils, comparable to the effect of thymalin. It was demonstrated that both the peptide drugs increased the production of pro-(TNFa, IL-1) and antiinflammatory (IL- 10) cytokines in the culture of intact cells of peripheral blood in vitro. It is essential that when tinrostim was used in 10-fold different doses (0.005 mg / kg and 0.05 mg /kg) in mice, the effect of the lower dose was comparable to the effect of the higher dose.
Study Information
pubmed
2013