Peptides of pineal gland and thymus prolong human life.
Khavinson. Vladimir Kh VKh; Morozov. Vyacheslav G VG
Key Findings
- Thymalin (and Epithalamin) improved cardiovascular, endocrine, immune, and nervous system markers in seniors.
- Incidence of respiratory infections, heart disease, hypertension, osteoarthritis and osteoporosis dropped 2‑ to 2.4‑fold in treated groups.
- Overall mortality was reduced 2‑fold with Thymalin alone, 1.6‑1.8‑fold with Epithalamin, and up to 4‑fold when both were used together over several years.
Practical Outcomes
- For biohackers interested in longevity, the data suggest that a multi‑year regimen of Thymalin (often combined with Epithalamin) could meaningfully lower disease risk and extend healthy lifespan in people over 60. However, the study does not detail exact dosing, frequency, or formulation, so anyone considering use should start with low‑dose protocols from reputable suppliers and monitor health markers closely.
Summary
A long‑term study in 266 older adults found that taking the thymus‑derived peptide Thymalin (and the pineal peptide Epithalamin) for a few years helped normalize heart, hormone, immune and nervous system functions, cut the rates of common age‑related diseases, and lowered death rates by roughly half compared with untreated people.
Abstract
Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years. The bioregulators were applied for the first 2-3 years of observation. The obtained results convincingly showed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism. Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control. Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0-2.1-fold in the Thymalin-treated group; 1.6-1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin as compared to the control. A separate group of patients was treated with Thymalin in combination with Epithalamin annually for 6 years and their mortality rate decreased 4.1 times as compared to the control. The obtained data confirmed the high geroprotective efficacy of Thymalin and Epithalamin and the expediency of their application in medicine and social care for health maintenance and age-related pathology prevention in persons over 60 to prolong their active longevity.
Study Information
pubmed
2003