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Thymalin

Thymulin, Thymic Factor, Serum Thymic Factor, Facteur Thymique Serique

Quick Stats
Studies 202
Trials 37
Overview Studies Clinical Trials
Score 2
1989 pubmed

[Characteristics of memory in MRL/1 mice and the effect of thymic peptides].

Melekhin. V D VD; Pleskovskaia. G N GN; Leshchenko. G Ia GIa; Siniachenko. V V VV; Nasonova. V A VA

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Key Findings

  • Thymalin reduced the speed of forming new memory traces in both normal and arthritis‑prone mice.
  • It improved the consolidation and retention of those memories, with a stronger effect in the arthritis‑prone MRL/1 mice.
  • The study links thymus‑derived peptides to immune‑mediated regulation of brain homeostasis.

Practical Outcomes

  • For biohackers, the data suggest thymalin might influence memory processes, potentially aiding retention in people with autoimmune issues, but it also appears to slow new learning. The mouse dose (≈8 mg/kg IP) does not translate directly to human protocols, so no concrete dosing recommendation can be made. More human‑focused research is needed before incorporating thymalin for cognitive or anti‑aging purposes.

Summary

In a mouse model of rheumatoid arthritis, a single injection of the thymic peptide thymalin (0.2 mg per mouse) slowed the initial learning of a new habit but helped the mice keep that memory better, especially in the arthritis‑prone strain. The authors think this reflects thymalin’s role in immune‑brain communication.

Abstract

By means of methods of active and passive getting rid of electrical-pain irritation we showed that in mice MRL/1--the model of rheumatoid arthritis (RA)--as compared with CBA (control) the process of forming a developed habit engram (DHE) was slowed down and its keeping was impaired. Thymic peptides (thymalin--0.2 mlg/mice intraperitoneally) suppressed the process of forming DHE irrespective of mice line and improved the process of its consolidation and keeping especially in mice MRL/1. Memory impairment in mice with genetical predisposition to the development of autoimmune process (MRL/1) is considered from view of the authors' developed hypothesis about thymus as an organ of antisystem of immune control of homeostasis and RA as an adaptation disease.

Study Information

Provider

pubmed

Year

1989