[THE STUDY OF THE EFFECTS OF ANXYOLYTIC, ANTIOXIDANT, IMMUNOCORRECTOR AND HYPERBARIC OXYGENATION ON THE DYNAMICS OF MAIN BLOOD GAS AND ELECTROLYTE INDICES AND BEHAVIORAL RESPONSE IN EXPERIMENTAL STRESS MODEL].
Govsh. E V EV; Podsevatkin. V G VG; Blinov. D S DS; Kiryukhina. S V SV; Podsevatkina. S V SV; Bochkareva. N V NV
Key Findings
- The thymogen‑mexidol‑hyperbaric oxygen combo reduced diazepam‑induced behavioral deficits in stressed mice
- Blood gas measurements improved: higher oxygen tension, normalized carbon dioxide pressure, and restored acid‑base balance
- The authors propose the combination could be used to treat stress‑related disorders
Practical Outcomes
- The results are interesting but limited to mice and involve multiple interventions, so they don’t translate into a clear, actionable protocol for humans. Biohackers should wait for human trials before considering thymogen, especially on its own, for stress or performance enhancement.
Summary
In a mouse study, giving a mix of the peptide thymogen, the drug mexidol, and hyperbaric oxygen helped reduce stress‑related behavior problems caused by diazepam and improved blood oxygen and acid‑base balance, suggesting it might help stress‑related conditions, but it’s only an animal test and not ready for human use.
Abstract
Experiments on the model of immobilization stress in albino mice showed that a combination of mexidol, thymogen, and hyperbaric oxygenation reduced adverse effects of diazepam on behavioral response of animals in the black-and-white chamber and elevated cross maze tests and led to optimization of the blood gas composition as manifested by increased oxygen tension, normalization of the partial pressure of carbon dioxide, and restoration of the acid-base balance and blood bicarbonate level. The proposed combined treatment can be recommended for the treatment of patients with stress-induced pathology.
Study Information
pubmed
2016