Thymogen

Glu-Trp, EW dipeptide, Oglufanide, L-Glutamyl-L-tryptophan

A synthetic dipeptide that modulates the immune system by enhancing T-cell differentiation, cytokine production, and overall immune response.

Molecular Profile

Formula C₁₆H₁₉N₃O₅

Mol. Weight 333.34 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Intramuscular (IM) 50-100 mcg/day	50-100 mcg/day	High (95%)	INT
Intranasal 100 mcg/day	100 mcg/day	Moderate (70%)	INT
Oral 250-500 mcg/day	250-500 mcg/day	Low (10%)	ORA

How It Works

How It Works: Thymogen acts as an immunomodulator by regulating gene expression and influencing various immune cell functions, thereby enhancing the body's defense mechanisms.

Regulates gene expression for heat-shock proteins, cytokines, and gerontogenes.
Activates differentiation, proliferation, and reduces apoptosis of immune cells, particularly T-cells.
Enhances cellular and humoral immunity reactions and nonspecific resistance.
Stimulates regeneration processes and normalizes blood parameters in immunodeficiency states.

Pairs Well With

Latest Clinical Trials

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Completed NA NCT06801951

Oral Supplement and Acute Resistance Exercise

Texas A&M University

INTERVENTIONAL

Updated Dec 15, 2025

Recruiting PHASE3 NCT06166030

IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.

Federal University of São Paulo

INTERVENTIONAL

Updated Dec 15, 2025

Not Yet Recruiting NA NCT06566157

PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults.

University of Southampton

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 3

pubmed May 6, 2024

The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.

Deigin. Vladislav V; Linkova. Natalia N; Vinogradova. Julia J; Vinogradov. Dmitr...

The paper explains that the same two‑amino‑acid peptide can have opposite effects on the immune system depending on its handedness: the natural L‑form (Thymogen) boosts immunity, while the mirror‑image D‑form (Thymodepressin) dampens it. This shows that flipping a peptide’s chirality can switch it from a stimulant to a suppressor, opening the door to custom‑designed immune‑modulating peptides.

Utility 2

pubmed Oct 20, 2023

Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.

Chulanova. A A AA; Smakhtin. M Yu MY; Bobyntsev. I I II; Mishina. E S ES; Artyus...

In a rat study, the immune‑boosting peptide Thymogen and new versions of it (with a D‑alanine amino acid added to the ends) helped protect the liver from damage caused by a toxic chemical. The modified peptides, especially when D‑alanine was attached to the C‑end, reduced oxidative stress and promoted liver cell repair more than regular Thymogen.

Utility 2

pubmed Feb 10, 2020

Novel platform for the preparation of synthetic orally active peptidomimetics with hemoregulating activity. II. Hemosuppressor activity of 2,5-diketopiperazine-based cyclopeptides.

Deigin. Vladislav V; Ksenofontova. Olga O; Yatskin. Oleg O; Goryacheva. Alexandr...

Scientists created new oral versions of a tiny protein fragment (a dipeptide) that can calm down the bone‑marrow blood‑forming system. The original Glu‑Trp peptide boosts immunity (the drug Thymogen), but flipping both amino acids to their mirror‑image (D‑Glu‑D‑Trp) flips the effect, suppressing blood‑cell growth. The study shows this flip works even when the peptide is built into a ring‑shaped molecule that can be taken by mouth.

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