Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.
Chulanova. A A AA; Smakhtin. M Yu MY; Bobyntsev. I I II; Mishina. E S ES; Artyushkova. E B EB; Smakhtina. A M AM
Key Findings
- Thymogen and its D‑Ala analogues lowered oxidative damage markers (malondialdehyde) in a toxic liver injury model.
- All peptides boosted liver cell regeneration, with the C‑terminal D‑Ala version showing the strongest effect.
- Adding D‑alanine to Thymogen increased both its antioxidant and hepatotropic (liver‑supporting) actions compared to the unmodified peptide.
Practical Outcomes
- For biohackers interested in liver health, this suggests that Thymogen‑type peptides might have protective effects, but the evidence is limited to animal models. No human dosing or safety data are provided, so any experimentation should be approached with caution and preferably under medical supervision. The study highlights the potential value of peptide modifications (like adding D‑alanine) for enhancing efficacy.
Summary
In a rat study, the immune‑boosting peptide Thymogen and new versions of it (with a D‑alanine amino acid added to the ends) helped protect the liver from damage caused by a toxic chemical. The modified peptides, especially when D‑alanine was attached to the C‑end, reduced oxidative stress and promoted liver cell repair more than regular Thymogen.
Abstract
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy. Intragastric administration of carbon tetrachloride for 5 days caused the development of fat degeneration of hepatocytes, a decrease in catalase activity, and an increase in malondialdehyde concentration. Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes; Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen. Inclusion of D-Ala enhanced the effect of Thymogen on the processes of regeneration in hepatocytes and the antioxidant effect under conditions of acute carbon tetrachloride hepatopathy. The highest efficiency was achieved when the amino acid was added to the C-end of the molecule.
Study Information
pubmed
2023
2023-10-20T00:00:00.000Z
10.1007/s10517-023-05929-5
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