[The pharmacological correction of the immune homeostasis disorders in acute dichloroethane poisoning].
Zabrodskiĭ. P F PF; Gryzunov. A V AV
Key Findings
- Thymogen (10 mg/kg daily for 3 days) restored reduced non‑specific immune resistance after acute dichloroethane poisoning in rats and mice
- Combined use of thymogen and dipyroxim enhanced the T‑dependent humoral immune response
- Dipyroxim’s effect was linked to restoring certain esterases in immune cells
Practical Outcomes
- For most biohackers, this research isn’t directly actionable because it’s an animal study on a rare chemical poisoning. It suggests thymogen might boost immune function after severe toxin exposure, but there’s no evidence for everyday use, dosage, or safety in humans.
Summary
In rats and mice that were poisoned with a toxic chemical, giving the peptide thymogen (10 mg/kg for three days) helped bring back their overall immune strength and specific immune reactions, similar to another drug called dipyroxim. The study was done in animals, not people, and focused on a very specific poisoning scenario.
Abstract
Experiments on Wistar rats and noninbred mice showed that dipyroxim (10 mg/kg administered 3 times per 24 h) and thymogen (10 mg/kg daily for 3 days) restore the reduced under the effect of acute dichlorethane poisoning in a dose of 0.75 LD50 the organism's anti-infectious unspecific resistance and the main humoral and cell immune reactions. Summing of the effects of the drugs under study was encountered in the case of the T-dependent humoral immune response. The effect of dipyroxim was due to restoration of alpha-naphthyl-AS-acetatesterase of immunocytes and, possibly, other types of esterases of T-cells, macrophages, and monocytes.
Study Information
pubmed
1999