[Effect of low doses of ionizing radiation on thymus-dependent humoral immune response and the polyclonal activation of B lymphocytes].
Sharetskiĭ. A N AN; Surinov. B P BP; Abramova. M R MR
Key Findings
- Low‑dose gamma radiation (10 cGy) increases thymus‑dependent humoral immunity and polyclonal B‑cell activation in mice
- Hydroquinone injection eliminates the radiation‑induced B‑cell activation
- Thymogen significantly reduces the radiation‑induced immune stimulation and the subsequent drop in antibody formation
Practical Outcomes
- Thymogen may help dampen unintended immune activation from low‑level radiation exposure, but the effect is modest and observed only in mice. For most biohackers, this isn’t a direct protocol change, though it suggests caution when combining thymogen with environments that involve low‑dose radiation. More human data are needed before practical recommendations.
Summary
In mice, a tiny amount of gamma radiation (10 cGy) temporarily ramps up the immune system’s antibody response and activates B‑cells, but this boost is followed by a later drop in antibody production. Giving the peptide thymogen cuts down this radiation‑driven immune boost, while a chemical called hydroquinone can block it entirely.
Abstract
The exposure of mice to low dose of gamma-rays (10 cGy, 1 cGy/min) increased thymus-dependent humoral immune response and polyclonal activation of B-cells. Injection of hydroquinone eliminated radiation-induced augmentation of polyclonal response of B-lymphocyte. Thymogen decreased significantly the radiation-induced immunostimulation. The study of the dynamics of primary immune response showed that the period of radiation-induced elevation was followed by the phase of profound reduction of antibody formation. Possible negative consequences of action of low doses of ionizing radiation on immune system is discussed.
Study Information
pubmed
2000