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Thymogen

Glu-Trp, EW dipeptide, Oglufanide, L-Glutamyl-L-tryptophan

Quick Stats
Studies 94
Trials 51
1996 pubmed

[The antagonistic properties of bacteria isolated from the digestive tract of female mink housed in the area of the Chernobyl Atomic Electric Power Station].

Sudenko. V I VI; Groma. L I LI; Podgorskiĭ. V S VS

Key Findings

  • Lactobacillus species dominate different parts of the mink gut (L. helveticus in stomach, L. coryniformis in small intestine, L. casei in large intestine)
  • Younger (1.5‑year‑old) minks have higher antagonistic activity in their gut bacteria
  • Minks treated with thymogen showed increased antibacterial activity in specific Enterococcus strains

Practical Outcomes

  • The findings are specific to wild minks and do not provide actionable guidance for human health or biohacking protocols. There is no evidence that thymogen will have similar effects on human gut bacteria or immunity, so the study offers little practical value for the target community.

Summary

The study looked at gut bacteria from female minks living near Chernobyl and found different types and amounts of bacteria in various gut sections, with younger minks showing stronger antibacterial activity. Some minks were given the peptide thymogen, which seemed to boost the antibacterial properties of certain Enterococcus strains, but the research was done in animals, not people.

Abstract

Differences in species composition, number and level of antagonistic activity of bacteria isolated from the digestive tract of Chernobyl female minks of various age and with different immunological state have been established. Prevalence of anaerobes (bifidobacteria) and microaerophils (lactic acid bacteria) with the increase of microorganisms concentration along the channel: stomach, small and large intestine (10(7)-10(10)/g) was found in all the departments of digestive tract of minks. Among the identified lactic-acid bacteria Lactobacillus helveticus (10(7)-10(8)/g) prevailed in the stomach of the studied female minks, L. coryniformis (10(9)-10(10)/g) in the small intestine, L. casei (10(10)/g) in the large one. Antagonistic activity was most expressed in the strains of L. helveticus and L. casei, isolated from the younger (1.5 year-old) minks. Enterococcus faecalis isolated from the stomach of 1.5 year-old female minks was distinguished by the greatest antagonistic activity among identified enterococci. Strains of E. faecium isolated from the thin intestine of the young female minks (1.5 year-old) and from the large intestine of more nature animals (2.5 years) who received thymogen were characterized by the most expressed antibiosis among enterococci isolated bacteria a conclusion was made that the mechanisms of inhibitory effect of the studied microorganisms are underlied by not only their capacity to form organic acids but also by the capacity to produce antibiotic products.

Study Information

Provider

pubmed

Year

1996