[A clinical and experimental validation of the use of Stimuloss in patients with chronic generalized periodontitis].
Fedosenko. T D TD; Vladimirova. L G LG; Ivasenko. I N IN
Key Findings
- Hydroxyapatite promotes bone‑cell biosynthesis in vitro
- Thymogen added for antibacterial effect does not impair hydroxyapatite’s bone‑building action
- In a clinical trial, the Stimulos sponge with thymogen reduced gum inflammation and increased alveolar bone height and density
Practical Outcomes
- For biohackers focused on bone and oral health, thymogen appears safe to combine with hydroxyapatite‑based supplements aimed at supporting jaw bone regeneration. While not a standalone longevity hack, it could be added to a gum‑care regimen, but optimal dosing and long‑term effects still need more study.
Summary
A study tested a sponge containing hydroxyapatite, an antibacterial agent, and the peptide thymogen on gum disease. In lab tests, hydroxyapatite boosted bone‑cell activity and adding thymogen didn’t stop this effect. In 66 people with chronic periodontitis, the sponge reduced inflammation and helped regrow and strengthen the jaw bone.
Abstract
The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug. Trials of Stimulos in 66 patients with chronic generalized periodontitis demonstrated its high efficacy, particularly of the compositions containing immunostimulants: inflammation disappeared and the height of alveolar osseous tissue increased, as did bone compactness.
Study Information
pubmed
1997