[Adaptive response in vivo: reasons for increase of radioresistance in CFU-S].
Semenets. T N TN; Semina. O V OV; Poverennyĭ. A M AM; Deĭgin. V I VI; Korotkov. A M AM; Saenko. A S AS
Key Findings
- Low‑dose irradiation pre‑conditions CFU‑S cells, increasing their radio‑resistance.
- PolyI‑PolyC injection before a high radiation dose further raises colony formation.
- Thymogen administration raises colony yield in both adapted and non‑adapted mice to the same extent.
Practical Outcomes
- Thymogen appears to support blood‑stem‑cell recovery after radiation, but the study is in mice and uses specific irradiation protocols. No human dosing or safety data are provided, so biohackers should treat this as preliminary evidence and await more research before applying it.
Summary
In mice, a tiny amount of radiation makes blood‑forming stem cells tougher, and giving a synthetic RNA (PolyI‑PolyC) before a big radiation dose helps them grow even more. Adding the peptide thymogen boosts stem‑cell colonies equally in both pre‑conditioned and normal mice, suggesting it can enhance recovery after radiation stress.
Abstract
The data concerning the reasons of CFU-S radioresistance increase after low dose irradiation of mice were obtained; the reparation processes in CFU-S adapted by low dose irradiation were shown to be more active than in intact ones. Colony formation increase was demonstrated to be more pronounced in adapted animals when they had been injected by 50 mcg of synthetic polyribonucleotide PolyI-PolyC two days before irradiation in challenge dose. The thymogen immunomodulator administration to adapted and intact donor animals leads to the increase of colony yield in equal extent.
Study Information
pubmed
1993