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Thymogen

Glu-Trp, EW dipeptide, Oglufanide, L-Glutamyl-L-tryptophan

Quick Stats
Studies 94
Trials 51
Overview Studies Clinical Trials
Score 2
1989 pubmed

[Inhibiting effect of thymogen on the development of tumors of the esophagus and forestomach induced by N-nitrososarcosine ethyl ester in rats].

Bespalov. V G VG; Troian. D N DN; Petrov. A S AS; Morozov. V G VG; Khavinson. V Kh VKh

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Key Findings

  • Thymogen reduced tumor incidence by 12% in rats exposed to N‑nitrososarcosine ethyl ester
  • Tumor multiplicity was 1.7‑fold lower with thymogen treatment
  • The control peptide pulmolin showed no impact on tumor development

Practical Outcomes

  • The results suggest thymogen may have a weak anti‑cancer effect in rodents, but the evidence is far too limited for any real‑world dosing or longevity protocol. Biohackers should view this as preliminary data that needs extensive human research before considering use.

Summary

In a rat study, the synthetic peptide thymogen slightly lowered the number and size of esophagus and stomach tumors caused by a chemical carcinogen, cutting tumor occurrence by about 12% and reducing tumor count per animal by roughly 40%. The effect was modest and seen only in this specific animal cancer model.

Abstract

Immunostimulating synthetic peptide thymogen being an analog of the thymus polypeptide drug thymalin was studied for its effect on carcinogenesis of the esophagus and forestomach in male rats. Rats received N-nitrososarcosine ethyl ester (NSEE) per os in the daily dose of 100 mg/kg of body weight during 8 weeks. After cessation of the carcinogen administration rats were treated with thymogen (the daily dose of 10 micrograms per rat) or immune-inactive polypeptide drug pulmolin from the alveolar tissue of lung (the daily dose of 0.5 mg per rat) during the following 32 weeks. Animals were killed 40 weeks after the experiment beginning. NSEE induced the esophagus and forestomach tumours, mainly papillomas and rarely carcinomas, practically in all rats, more than 5 tumours per rat, on the average. Thymogen decreased the tumour incidence by 12% and made tumour multiplicity 1.7 times as low. Pulmolin did not influence development of these tumours.

Study Information

Provider

pubmed

Year

1989