[Effect of thymic immunomodulators on the system of cyclic nucleotides of splenic T-lymphocytes after BCG vaccination].
Demidov. S V SV; Kostromin. A P AP; Chernyshenko. E F EF; Kuĭbeda. V V VV; Borovok. M I MI
Key Findings
- BCG vaccination increased activity of enzymes that create and degrade cAMP and cGMP in T‑cells.
- Thymogen and thymalin preferentially boosted cGMP synthesis, shifting the cAMP/cGMP ratio downwards.
- Vilosene increased the cAMP/cGMP ratio during a repeat BCG injection.
Practical Outcomes
- The findings are mostly mechanistic and done in animals, so they don’t give clear, actionable advice for human biohackers. At best, they hint that thymogen might influence immune signaling pathways, but no dosage, timing, or health benefit is established for practical use.
Summary
In a guinea‑pig study, researchers gave three thymus‑derived peptides (thymogen, thymalin, vilosene) while the animals were vaccinated with BCG. They measured enzymes that control the cell signals cAMP and cGMP in T‑cells. The disease raised both the making and breaking down of these signals, and thymogen or thymalin mainly pushed up cGMP production, lowering the cAMP/cGMP balance, while vilosene did the opposite after a second vaccine dose.
Abstract
The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination. It was shown that the disease was accompanied by increased activity of enzymes of anabolism and catabolism of cyclic nucleotides. Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level. At the same time vilosene increased this value in the process of a repeated BCG injection.
Study Information
pubmed
1990