[The effect of thymogen on the postintoxication immunodeficiency state induced by acute acetonitrile poisoning].
Zabrodskiĭ. P F PF
Key Findings
- Acute acetonitrile poisoning in rats suppresses both humoral (antibody) and cellular immune responses.
- Thymogen treatment reversed most of the immune deficits caused by the toxin.
- The study was performed in Wistar rats, not humans.
Practical Outcomes
- For biohackers, the data suggest thymogen might help recover immune function after severe chemical stress, but the evidence is limited to animal models and a very specific toxin exposure. There is no dosage guidance or safety data for humans, so it’s not ready for routine use in longevity or performance protocols.
Summary
In rats that were poisoned with a chemical called acetonitrile, their immune systems got weaker—fewer antibody‑producing cells, weaker natural killer cells, and reduced macrophage activity. Giving them thymogen, a peptide derived from the thymus, largely restored those immune functions.
Abstract
It was demonstrated in experiments on Wistar rats that acute acetonitrile (AN) intoxication (0.8L D50) causes decrease of antibody-forming cells in the spleen, mainly those related to the T-dependent antigen, functioning of the natural cell-killers, antibody-dependent cytotoxicity, the ability of macrophages to induce the humoral immune responses and the delayed hypersensitivity reaction. Thymogen restored most of the humoral and cell immune reactions which were reduced by AN.
Study Information
pubmed
1999