[The effect of thymogen on the chromosome aberration level in a culture of human peripheral blood lymphocytes].
Rushkovskiĭ. S R SR; Chegrinets. S E SE; Bezrukov. V F VF; Khrapunov. S N SN
Key Findings
- High thymogen concentrations (10‑1000 µg/mL) suppress lymphocyte proliferation.
- Low thymogen concentrations (0.001‑1 µg/mL) are not mutagenic and do not reduce cell division.
- Low thymogen doses significantly reduce formaldehyde‑induced chromosome aberrations.
Practical Outcomes
- For biohackers, the data suggest that very low thymogen doses might offer some DNA‑protective effects without harming cell health, but the study is in vitro and does not define a safe oral or injectable dose for humans. Until human trials are available, any use should be approached cautiously, focusing on the lowest possible dose if experimenting.
Summary
A lab study found that tiny amounts of the peptide thymogen can lower DNA damage caused by formaldehyde in human blood cells, while higher doses hurt cell growth. Low doses didn’t cause mutations on their own.
Abstract
The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected. High thymogene concentration (1000, 100, and 10 micrograms/ml) significantly decreased the proliferative activity of lymphocytes in culture. Low thymogene concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) didn't decrease the mitotic activity of culture and hadn't mutagenic activity. Thymogene concentrations 1.0; 0.1; and 0.001 microgram/ml significantly decreased the frequency of formaldehyde-induced chromosome aberrations in lymphocytes. Possible mechanisms of gene protection by thymogene is discussed.
Study Information
pubmed
1996