[Application of immunomodulators for correction of changes in the immune system in conditions of experimental hypothyroidism].
Zamotaieva. H A HA; Sydorenko. D S DS; Stepura. N M NM; Zakharchenko. T F TF; Hoĭdash. M M MM; Skvyrs'ka. L M LM
Key Findings
- Thyroid removal in mice suppresses several immune functions, including thymus activity, IL‑2 production, and killer cell activity.
- Thyroxine hormone replacement alone only partially restores these immune deficits.
- Adding the immunomodulator thymogen (or polyoxydonium) after hormone normalization further improves immune recovery.
Practical Outcomes
- For biohackers interested in immune support during thyroid issues, this study suggests that simply fixing thyroid hormone levels may not be enough; adding an immune‑modulating supplement like thymogen could enhance recovery. However, the evidence is limited to mice, so human dosing, safety, and effectiveness remain uncertain.
Summary
In mice that had their thyroid removed, the researchers found that the immune system got weaker (lower thymus activity, less IL‑2, weaker killer cells, and more immune complexes). Giving the hormone thyroxine plus the immune‑boosting drugs thymogen or polyoxydonium helped, but only partially. When the thyroid hormone levels were first corrected, adding thymogen or polyoxydonium gave a bigger boost and helped the immune system recover more fully.
Abstract
Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium. In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well. The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part. The immunomodulators application, under condition of the hypothyrosis compensation occurrence, have had promoted the essential raising of their therapeutic action and secured the immune state restoration after thyroidectomy performance.
Study Information
pubmed
2004