[Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions].
Podsevatkin. V G VG; Kiriukhina. S V SV; Podsevatkin. D V DV; Podsevatkina. S V SV; Blinov. D S DS
Key Findings
- Combined treatment reduced anxiety-like behavior in immobilized mice.
- Locomotor and exploratory activity increased with the therapy.
- Cortisol (cortisole) levels were normalized after the combined intervention.
Practical Outcomes
- The study suggests that a multi‑component approach can improve stress responses in mice, but it does not isolate thymogen’s effect or provide human dosing guidance. For biohackers, the result is not directly actionable because it involves several drugs and hyperbaric oxygen, making translation to a simple at‑home protocol unclear.
Summary
In stressed mice, a mix of a drug called mexidole, a sedative (diazepam), a peptide called thymogen, and hyperbaric oxygen helped lower anxiety, boost movement and exploration, and bring cortisol levels back to normal. The authors say this works by affecting the immune and hormone systems.
Abstract
Experiments on white mice under the model immobilization stress condition showed that a combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation (pathogenetic therapy) leads to optimization of the behavioral reactions, which is manifested by a decrease in the level of anxiety, increase in the locomotor and research activity, and normalization of the cortisole level. This effect is explained by a complex pharmacological action of all factors on the immune and endocrine mechanisms of the stress pathogenesis.
Study Information
pubmed
2008