[Application thymogen for preoperative preparation of elderly patients with tumor processes in abdominal cavity].
Smirnov. V S VS; Petlenko. S V SV; El'tsin. S S SS
Key Findings
- Intranasal Thymogen (100 mg daily) for 7 days before surgery restored structural and functional cellular immunity in elderly patients.
- Patients receiving Thymogen experienced a significant reduction in the number and severity of postoperative complications.
- The postoperative recovery period was shortened compared to the placebo group.
Practical Outcomes
- For anyone planning major abdominal surgery, especially older adults, a short pre‑operative course of intranasal Thymogen could be a low‑risk way to strengthen immune defenses and speed recovery. The study suggests a simple 7‑day regimen (100 mg nasal spray daily) that may be incorporated into pre‑surgical preparation protocols.
Summary
Giving 100 mg of Thymogen as a nasal spray each day for a week before abdominal cancer surgery helped older patients boost their immune cells, cut the number of complications after the operation, and recover faster.
Abstract
A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out. The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery. The isotonic sodium chloride solution for the placebo group in the same scheme was used. The preoperative use of Thymogen proved to be useful to restore the structural and functional parameters of cellular immunity. Immunomodulatory therapy resulted in the significant decrease in the number and range of post-operative complications and the shorting of the postoperative period.
Study Information
pubmed
2011