Reciprocal effect of optical isomerism of EW-dipeptides on immune response.
Deigin. V I VI; Poverenny. A M AM; Semina. O V OV; Semenets. T N TN
Key Findings
- D‑(EW) dipeptide suppresses spleen colony formation and stem‑cell entry into S‑phase in mouse bone marrow.
- L‑(EW) dipeptide does not affect normal bone marrow but promotes recovery after 1 Gy radiation.
- The inhibitory effect of D‑(EW) can be reversed by injecting thymic cells into the recipient.
Practical Outcomes
- These results are early‑stage animal data and do not provide dosage, safety, or human efficacy information. For biohackers, there is no clear protocol to use EW dipeptides for immune or performance benefits, and the findings suggest caution rather than a new supplement strategy.
Summary
Researchers tested two mirror‑image versions of a tiny protein piece (EW dipeptide). The D‑form blocked the growth of blood‑forming cells in mouse bone marrow, while the L‑form helped those cells recover after low‑dose radiation. Adding thymus cells could cancel the D‑form’s blocking effect. The D‑form also stopped stem cells from entering the DNA‑making phase.
Abstract
Dipeptides of the EW-sequence, consisting of D-amino acids, were shown to inhibit spleen colony formation both after in vitro treatment of bone marrow and after the peptide injection to the donor 2-48 h prior to bone marrow taking. The inhibiting effect of D-(EW) peptides can be eliminated by injection of thymic cells to the recipient. L-(EW) peptides have no influence on colony forming activity of intact bone marrow cells but stimulate regeneration of colony formation by irradiated (1 Gy) bone marrow. Unlike L-(EW), the D-(EW) peptides suppress the development of hemopoietic stem cells into the S-phase. Supposedly, D-(EW) represent a new generation of immunoactive peptides possessing of inhibiting activity.
Study Information
pubmed
1999
1999-03-15T00:00:00.000Z
10.1016/s0165-2478(98)00149-7