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Thymosin-beta-4-fragment

Ac-SDKP, Goralatide, Seraspenide

A tetrapeptide fragment of thymosin beta-4 that inhibits inflammation, reduces fibrosis, and regulates hematopoietic stem cell proliferation.

Quick Stats
Studies 83
Trials 3
Formula C20H33N5O9
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Utility 1
pubmed Dec 17, 2013

In situ proteomic analysis by MALDI imaging identifies ubiquitin and thymosin-β4 as markers of malignant intraductal pancreatic mucinous neoplasms.

Rebours. Vinciane V; Le Faouder. Julie J; Laouirem. Samira S; Mebarki. Mounya M; Albuquerque. Miguel...

Researchers used a special imaging technique to look at proteins in early pancreatic tumors and found that both ubiquitin and a piece of the protein thymosin‑beta‑4 are higher in the more dangerous forms. This suggests they could be used as markers to decide if surgery is needed, but the study does not give any advice on using these peptides for health or performance.

Utility 1
pubmed 2003

Use of ProteinChip array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) to identify thymosin beta-4, a differentially secreted protein from lymphoblastoid cell lines.

Diamond. Deborah L DL; Zhang. Yanni Y; Gaiger. Alexander A; Smithgall. Molly M; Vedvick. Thomas S TS...

Scientists used a special mass‑spectrometry chip to compare proteins released by normal B‑cells and virus‑transformed B‑cells. They found a strong signal for a protein called thymosin beta‑4 that was much higher in the transformed cells, confirming it as a cancer‑related marker.

Utility 1
pubmed Aug 24, 2004

Factor XIIIa incorporates thymosin beta4 preferentially into the fibrin(ogen) alphaC-domains.

Makogonenko. Evgeny E; Goldstein. Allan L AL; Bishop. Paul D PD; Medved. Leonid L

The study shows that an enzyme called factor XIIIa can attach the peptide thymosin‑beta‑4 to blood clot proteins (fibrin and fibrinogen), especially in a specific part of the clot protein called the alphaC‑domain. This attachment only happens when factor XIIIa is active, and it doesn’t happen through simple binding without the enzyme.

Utility 1
pubmed 1989

Synthesis of a thymosin beta 4-like peptide, deacetyl-thymosin beta Xen4, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin (PHA) in uremic patients.

Abiko. T T; Sekino. H H

Scientists created a frog‑derived peptide similar to thymosin beta‑4 and showed that, in a lab test, it helped immune cells from kidney‑failure patients respond better to a stimulus. The work is purely experimental and does not provide a usable protocol for everyday supplementation.

Utility 1
pubmed Aug 15, 1989

MicroELISA method for the determination of thymosin beta 9 discriminating between thymosin beta 9 and the structurally closely related thymosin beta 4.

Mihelić. M M; Kalbacher. H H; Hannappel. E E; Voelter. W W

Scientists created a new lab test that can reliably tell the difference between two almost identical proteins, thymosin beta‑9 and thymosin beta‑4, by using a specific part of the beta‑9 protein to make antibodies. This is mainly a research tool and doesn’t give any new dosing or usage advice for people who take these peptides.

pubmed 1992

Assembly of polypeptide and protein backbone conformations from low energy ensembles of short fragments: development of strategies and construction of models for myoglobin, lysozyme, and thymosin beta 4.

Sippl. M J MJ; Hendlich. M M; Lackner. P P

Scientists created a computer technique that builds 3‑D models of short protein pieces by stitching together many possible shapes of tiny fragments. They tested it on known proteins and on the 43‑amino‑acid peptide thymosin‑beta‑4, and the predicted shapes matched the real ones, but the study doesn’t give any health‑related advice or dosing tips.

pubmed Dec 28, 1994

Theoretical and experimental epitope mapping of thymosin beta 4.

Becker. S S; Armbruster. F P FP; Müller. B B; Echner. H H; Kapurnotu. A A; Livaniou. E E; Mihel...

The paper simply maps which parts of the thymosin‑beta‑4 peptide are recognized by antibodies in rabbits, showing that the full‑length peptide triggers antibodies to three regions while a short fragment only triggers the front part. It doesn’t provide any health‑related data or guidance on using the peptide.

pubmed Nov 1, 1997

Mapping the binding site of thymosin beta4 on actin by competition with G-actin binding proteins indicates negative co-operativity between binding sites located on opposite subdomains of actin.

Ballweber. E E; Hannappel. E E; Huff. T T; Mannherz. H G HG

The paper maps where the small protein fragment thymosin‑beta‑4 attaches to actin and shows it shares a spot with part of the protein gelsolin and is pushed off when DNase I binds, indicating the sites work against each other.

pubmed Mar 15, 1996

The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization.

Li. X X; Zimmerman. A A; Copeland. N G NG; Gilbert. D J DJ; Jenkins. N A NA; Yin. H L HL

This study maps the mouse thymosin‑beta‑4 gene, shows it’s a single gene with a special version in immune cells, describes its promoter region, and places it on the X chromosome. It’s basic gene‑science and doesn’t give any tips on using the peptide for health or performance.

pubmed May 2, 2019

Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior.

Martelli. Claudia C; Serra. Riccardo R; Inserra. Ilaria I; Rossetti. Diana Valeria DV; Iavarone. Fed...

Scientists studied the protein makeup of a rare childhood brain tumor and found many proteins, including thymosin‑beta‑4, but the work is purely descriptive and doesn’t give any tips or treatments you can use.

pubmed Sep 28, 2016

The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation.

Weissinger. E M EM; Human. C C; Metzger. J J; Hambach. L L; Wolf. D D; Greinix. H T HT; Dickinson. A...

Scientists found a set of 14 tiny protein pieces in urine that can predict a serious complication called chronic graft-versus-host disease after a stem‑cell transplant, and six of those pieces come from a protein called thymosin‑beta‑4. This test can spot the disease weeks before symptoms appear, but it’s only useful for patients who have had a transplant, not for general health or performance goals.

pubmed Jun 19, 2013

Peptidomic Identification of Serum Peptides Diagnosing Preeclampsia.

Wen. Qiaojun Q; Liu. Linda Y LY; Yang. Ting T; Alev. Cantas C; Wu. Shuaibin S; Stevenson. David K DK...

Scientists identified a set of 19 blood peptides that can accurately detect preeclampsia, a pregnancy complication, and one of those peptides is a fragment of thymosin‑beta‑4. The study is about a diagnostic test, not about using the peptide for health improvement, so it doesn’t give any actionable advice for biohackers or longevity enthusiasts.

pubmed 1996

Characterization of natural peptides from bovine tissue using capillary electrophoresis, high performance liquid chromatography, matrix-assisted laser desorption ionization, and Edman degradation.

Weiler. A A; Stoeva. S S; Lehmann. R R; Grübler. G G; Paulus. G G; Voelter. W W

The paper describes fancy lab tricks to figure out the exact building blocks of a protein called beta‑thymosin from cow tissue. It’s about how scientists use different machines to separate and identify the peptide, not about how to use it for health or performance.

pubmed Mar 1, 1995

Intracellular degradation of the C-peptide of proinsulin, in a human insulinoma: identification of sites of cleavage and evidence for a role for cathepsin B.

Conlon. J M JM; Höög. A A; Grimelius. L L

The study looked at a pancreatic tumor and found that the C‑peptide part of proinsulin gets chopped up inside the tumor cells by an enzyme called cathepsin B, creating several short fragments, while insulin itself stays whole. This is a basic science finding and doesn’t give any direct advice or new uses for peptides like thymosin‑beta‑4‑fragment in everyday health or performance routines.

pubmed 1984

[Thymic hormones. Neuroendocrine interactions and clinical use in congenital and acquired immune deficiencies].

Martin-Du-Pan. R C RC

The article is a review of several thymic hormones (like thymosin alpha‑1, thymopoietin, thymulin) and how they affect the immune system, brain and endocrine glands, especially in people with immune deficiencies or autoimmune disease. It does not mention thymosin‑beta‑4‑fragment or give any dosing or protocol advice, so it isn’t directly useful for self‑experimenters looking for practical guidance.