Unknown
PHASE2
INTERVENTIONAL
NCT04407065
Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (\<50%) number of oocytes retrieved per number of follicles \> 14 mm in diameter on day of hCG administration
Interventions
Name:
Double trigger
Type:
DRUG
Description:
Final follicular maturation is triggered by the co-administration of GnRH-agonist (Triptorelin acetate, decapeptyl 0.2 mg, Slough, United Kingdom) and 10000 IU of HCG, 40 and 34 h prior to oocyte retrieval, respectively
Name:
HCG trigger
Type:
DRUG
Description:
Final follicular maturation is triggered by a dose of 10000 IU of HCG 36 h prior to oocyte retrieval
Primary Outcomes
Measure:
Number of oocytes retrieved
TimeFrame:
First day after oocyte retrieval
Description:
Trial Information
NCT ID
NCT04407065
Status
Unknown
Study Type
INTERVENTIONAL
Phases
PHASE2
Sponsor
Riyadh Fertility and Reproductive Health center
Last Updated
December 15, 2025