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Triptorelin

Decapeptyl, Trelstar, Gonapeptyl, Pamorelin

A synthetic GnRH agonist decapeptide that suppresses gonadotropin and sex hormone production for treating prostate cancer, endometriosis, and precocious puberty.

Quick Stats
Studies 178
Trials 100
Formula C64H82N18O13
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pubmed Mar 28, 2024

GnRH analogue triptorelin acetate induces ovulation in jennies during oestrus.

Fanelli. Diana D; Moroni. Rebecca R; Berti. Giovanni G; Camillo. Francesco F; Maltinti. Saverio S; R...

In a study on female donkeys, a single injection of the GnRH drug triptorelin caused ovulation in most cases and did so faster than doing nothing, similar to another GnRH drug. This shows the drug works to trigger ovulation in donkeys, but it doesn’t give any direct advice for human health or performance.

pubmed Feb 1, 2024

Peak serum luteinising hormone cut-off during gonadotropin-releasing hormone analogue test for diagnosing central precocious puberty was lower in girls with obesity as compared with girls with normal weight.

Sakornyutthadej. Natee N; Mahachoklertwattana. Pat P; Wankanit. Somboon S; Poomthavorn. Preamrudee P

The study looked at how the hormone‑triggering drug triptorelin is used in a test to diagnose early puberty in girls and found that overweight girls need a lower LH cut‑off (4 IU/L) than normal‑weight girls (5 IU/L).

pubmed Apr 30, 2024

Effectiveness of the triptorelin stimulation test compared with the classic gonadotropin-releasing hormone stimulation test in diagnosing central precocious puberty in girls.

Kim. Yu Jin YJ; Hwangbo. Jung J; Park. Kyu Hyun KH; Kang. Eungu E; Nam. Hyo-Kyoung HK; Rhie. Young-J...

The study compared two hormone‑stimulating tests to see if the drug triptorelin can replace the standard GnRH test for diagnosing early puberty in girls. It found that both tests gave similar hormone spikes and diagnosed a similar number of cases, and that measuring up to 120 minutes was enough.

pubmed Sep 13, 2024

Use of a Vaginally Administered Gel Containing the GnRH Agonist Triptorelin and a Single, Fixed-Time Artificial Insemination in Pigs under Commercial Conditions: Productive and Economic Impacts.

Crespo. Sara S; Gadea. Joaquín J

Researchers tested a gel with the hormone drug triptorelin in female pigs to make them ovulate at the same time, allowing a single insemination. It worked well in most cases and saved money for farms, but the study is about pig breeding, not human health.

pubmed Mar 22, 2025

Diagnosis Prostate Cancer via Molecular Computed Tomography Imaging based on Targeted Gold Nanoparticles.

Ghorbani. Farzaneh F; Abbasi. Samaneh S; Rabani. Fatemeh F; Khademi. Sara S; Montazerabadi. Alireza...

Scientists attached the peptide drug triptorelin to tiny gold particles to make a contrast agent that homes in on prostate cancer cells for CT scans. The new particles were safe in lab tests and gave a stronger X‑ray signal and clearer images than regular gold particles, but this is a medical imaging tool, not a supplement or therapy you can use yourself.

pubmed Mar 9, 2024

[A new way for the differential diagnosis of hypogonadotropic hypogonadism and constitutional delay of puberty in adolescent men aged 13.5-17 years].

Skorodok. Y L YL; Ioffe. I Y IY; Plotnikova. E V EV; Nagornaya. I I II; Zhelenina. L A LA; Kozhevnik...

Researchers made a simple scoring system that looks at four hormone levels (LH, FSH, testosterone, inhibin B) to tell whether a teenage boy’s delayed puberty is due to a medical problem (hypogonadotropic hypogonadism) or just a normal late start (constitutional delay). They used a drug called triptorelin to help confirm the diagnosis, but the method is meant for doctors treating adolescents, not for self‑experiments or performance enhancement.

pubmed Nov 20, 2023

Use of the Subcutaneous Triptorelin Stimulation Test for Diagnosis of Central Precocious Puberty.

Ahn. Jungmin J; Lee. Youngin Y; Gim. Seongmin S; Jeong. Hwalrim H

Researchers tested a skin‑injected hormone called triptorelin to see if it can replace the usual IV test for spotting early puberty in girls. They found that measuring a hormone (LH) 2 hours after the injection works well, but this is a medical diagnostic tool for children, not something useful for health‑optimizing adults.

pubmed Nov 24, 2022

A single blood sample for stimulated LH assayed by ICMA is useful for monitoring the treatment efficacy of triptorelin depot in girls.

Zhou. Yuan Y; Jia. Ruofan R; Kong. Fan-Sheng FS; Chen. Min M; Ren. Feng F; Xu. Zhuangjian Z; Ma. Yap...

The study shows that in girls receiving a puberty‑blocking drug (triptorelin), measuring the hormone LH just once after a stimulation test can reliably tell if the treatment is working, using specific cutoff values. This method is useful for doctors monitoring treatment, but it doesn’t provide new ways to use the peptide for health‑span, performance, or metabolic benefits that biohackers typically seek.

pubmed Apr 12, 2022

Triptorelin-functionalized PEG-coated biosynthesized gold nanoparticles: Effects of receptor-ligand interactions on adhesion to triple negative breast cancer cells.

Uzonwanne. Vanessa O VO; Navabi. Arvand A; Obayemi. John D JD; Hu. Jingjie J; Salifu. Ali A AA; Ghah...

Scientists attached the peptide triptorelin to tiny gold particles coated with PEG and showed in lab tests that these particles stick much more to aggressive breast cancer cells because those cells have lots of LHRH receptors. This is an early‑stage, laboratory finding and not a usable health or anti‑aging protocol.

pubmed Nov 29, 2023

Psychological Outcomes of 12-15-Year-Olds with Gender Dysphoria Receiving Pubertal Suppression in the UK: Assessing Reliable and Clinically Significant Change.

McPherson. Susan S; Freedman. David E P DEP

This study looked at teens with gender dysphoria who took the drug triptorelin to pause puberty and measured their mental health over three years. It found that a noticeable share of participants got worse on some psychological scales, while only a small number showed meaningful improvement, and overall benefits were limited. The research mainly informs medical practice for gender‑affirming care, not everyday health‑hacking.

pubmed Nov 6, 2021

Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty.

Shokri. Elnaz E; Heidarianpour. Ali A; Razavi. Zahra Z

A 12‑week program of combined aerobic and resistance exercise (60 minutes, three times a week) raised the good‑fat hormone adiponectin and lowered the bad‑fat hormone resistin in overweight/obese girls with early puberty who were already on the drug triptorelin. The exercise also slowed puberty markers, but after stopping training for four weeks the hormone benefits faded, though they didn’t disappear completely.

pubmed Jul 16, 2022

Unravelling a novel, promising and convenient tool for differential diagnosis of delayed puberty: GnRHa-stimulated inhibin B (GnRH-iB).

Chaudhary. S S; Walia. R R; Bhansali. A A; Dayal. D D; Sachdeva. N N; Singh. T T; Bhadada. S K SK

The study shows that giving a single dose of the peptide triptorelin and measuring a hormone called inhibin B a day later can accurately tell whether a teen’s delayed puberty is just a normal lag or a more serious hormone problem, but this is a medical diagnostic test, not a health‑boosting protocol for everyday use.

pubmed Jun 25, 2023

Short-term clinical and hormonal effects of a deslorelin implant on late-prepubertal bitches - Based on flare-up signs.

Karadağ. M A MA; Schäfer-Somi. S S; Demir. M C MC; Kuru. M M; Aslan. S S; Kaya. D D

The study tested a GnRH‑agonist implant (deslorelin) in young female dogs to see if it triggers early heat signs and hormone changes. Only some dogs showed heat signs, hormone levels rose only a little, and the response was highly variable, making it hard to predict. This research is about dog reproduction and doesn’t give useful guidance for human health or biohacking.

pubmed Sep 12, 2022

Modified Bismuth Nanoparticles: A New Targeted Nanoprobe for Computed Tomography Imaging of Cancer.

Mohammadi. Milad M; Khademi. Sara S; Choghazrdi. Yazdan Y; Irajirad. Rasoul R; Keshtkar. Mohammad M;...

Scientists made tiny bismuth particles that are coated with a peptide called triptorelin to help them stick to cancer cells for better CT scans. In lab tests they weren’t toxic and gave a modest boost in X‑ray signal compared to particles without the peptide, but this is only a proof‑of‑concept for imaging, not a health‑boosting product you can use yourself.

pubmed Mar 15, 2022

Ovulatory response to GnRH agonist during early and late fall in mares.

Spencer. Kianna M KM; Podico. Giorgia G; Megahed. Ameer A AA; Jones. Kristi L KL; Bittar. João...

In a study of 22 horses, giving a GnRH‑like drug (deslorelin) in the fall reliably triggered ovulation in about 90% of cycles, with timing and hormone levels staying pretty consistent whether the drug was given early or late in the season. Weather factors like temperature and humidity slightly changed follicle size, but overall luteal function looked normal.