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GHRH (1-29), GRF 1-29 NH2, Sermorelin acetate
A synthetic 29-amino acid analog of growth hormone-releasing hormone that stimulates pituitary gland to release growth hormone.
Brain. C E CE; Hindmarsh. P C PC; Brook. C G CG
In a small study, giving kids with slow growth a constant tiny dose of the peptide sermorelin under the skin for up to a year made them grow faster (about 2‑3 cm more per year). Their natural GH pulses stayed strong and didn’t wear out, and when the treatment stopped, growth went back to the old rate.
Dattani. M T MT; Winrow. A P AP; Tuil'Pakov. A A; Pringle. P J PJ; Hindmarsh. P C PC; Brook. C G CG;...
In a tiny study of four healthy men, giving short IV bursts of a growth‑hormone‑releasing hormone (the same kind of peptide found in sermorelin) caused spikes in both measured GH levels and the actual biological activity of GH. The bioactive GH peaked higher than what standard lab tests showed, but the effect was short‑lived and varied a lot between people.
Gelander. L L; Albertsson-Wikland. K K
In short children, the amount of growth hormone (GH) released after a single dose of a GH‑releasing hormone (like sermorelin) depends on how much GH the body has already been making. Kids who naturally secreted more GH over a full day tended to have a bigger response, but if they had a high GH spike in the three hours right before the test, the response was actually lower.
Clark. R G RG; Robinson. I C IC
In rats, giving the growth‑hormone‑releasing peptide (GHRF 1‑29, the same sequence used in sermorelin) in short, repeated bursts (pulses) speeds up growth and raises pituitary GH stores, while a steady, continuous infusion does not work. The effect shows up in normal rats and in rats that lack their own GHRF, meaning the peptide can boost growth if delivered the right way.
Memdouh. Siham S; Gavrilović. Ivana I; Ng. Kelsey K; Cowan. David D; Abbate. Vincenzo V
The study shows that labs can now reliably spot tiny amounts of growth‑hormone‑releasing‑hormone (GHRH) peptides like sermorelin in urine, thanks to a new sensitive test that catches even 1 ng/ml. It doesn’t tell you how to use sermorelin for health, just that anti‑doping agencies are getting better at catching it.
Prakash. A A; Goa. K L KL
Sermorelin is a lab-made peptide that mimics the hormone that tells the pituitary gland to release growth hormone. In kids with unexplained growth hormone deficiency, a single IV dose can help diagnose the problem, and daily injections can modestly boost growth, though not as much as the standard growth hormone drug. It’s generally safe, causing only mild flushing or injection-site pain.
Knoop. Andre A; Thomas. Andreas A; Fichant. Eric E; Delahaut. Philippe P; Schänzer. Wilhelm W;...
Researchers created a sensitive blood test that can spot sermorelin and similar growth‑hormone‑releasing peptides, even at very low levels. They found the drug stays intact in the blood for at least four hours and that a specific breakdown product shows up in humans but not in rats. This method could be used in anti‑doping labs to catch people using these peptides.
Kanashiro-Takeuchi. Rosemeire M RM; Takeuchi. Lauro M LM; Rick. Ferenc G FG; Dulce. Raul R; Treuer....
In a rat study, a drug that mimics the hormone that normally triggers growth hormone release (a GHRH‑agonist) was given a month after a heart attack and it helped the heart heal better, shrink the scar, and improve pumping ability, all without raising overall growth hormone levels. The benefits disappeared when a blocker of the same receptor was used, showing the effect is specific to that pathway.
Seitz. S S; Rick. F G FG; Schally. A V AV; Treszl. A A; Hohla. F F; Szalontay. L L; Zarandi. M M; Or...
Scientists tested a growth‑hormone‑releasing‑hormone blocker (JMR‑132) alone and together with the chemo drug docetaxel on aggressive breast‑cancer cells and in mice. Both treatments slowed tumor growth, but the combo cut tumor size by about 72%, far more than either alone.
Schally. Andrew V AV; Wang. Haibo H; He. Jinlin J; Cai. Renzhi R; Sha. Wei W; Popovics. Petra P; Per...
A lab study showed that a synthetic growth‑hormone‑releasing hormone (GHRH) agonist called MR409 actually slowed tumor growth in mice, even though it seemed to help cancer cells survive in a petri dish. This mixed result suggests the drug might have anti‑cancer effects, but it’s far from ready for human use.
Barabutis. Nektarios N; Akhter. Mohammad S MS; Uddin. Mohammad A MA; Kubra. Khadeja-Tul KT; Schally....
A lab study found that a GHRH‑blocking molecule called MIA‑602 can shield brain blood‑vessel cells from damage caused by hydrogen peroxide, a type of oxidative stress. It does this by turning on protective proteins (like p53) and turning off inflammation‑related pathways (RhoA, cofilin). The authors suggest this could help conditions where the blood‑brain barrier breaks down, such as Alzheimer’s or Parkinson’s disease.
Rieger. Angela C AC; Bagno. Luiza L LL; Salerno. Alessandro A; Florea. Victoria V; Rodriguez. Jose J...
In a pig model where kidney damage caused a type of heart failure that keeps the pumping ability normal but makes the heart stiff, daily injections of a growth‑hormone‑releasing hormone (GHRH) agonist (similar to sermorelin) improved heart relaxation, lowered pressure inside the heart, and changed heart proteins linked to stiffness. The drug also boosted calcium signals in heart cells, which are important for proper contraction and relaxation.
Muñoz-Moreno. Laura L; Arenas. M Isabel MI; Carmena. M José MJ; Schally. Andrew V AV; Prie...
The study found that blocking the hormone that normally triggers growth hormone release (GHRH) can also shut down cancer‑related growth signals (EGFR/HER2) in prostate cancer cells and tumors in mice. However, the work used experimental GHRH‑blocking compounds, not the commonly used sermorelin, and it was done in a cancer model, so it doesn’t give direct, safe ways to use sermorelin for health or performance.
Recinella. Lucia L; Chiavaroli. Annalisa A; Orlando. Giustino G; Ferrante. Claudio C; Veschi. Serena...
A mouse study found that a growth‑hormone‑releasing‑hormone blocker called MIA‑602 reduced anxiety‑like and depression‑like behavior, likely by cutting inflammation and oxidative stress and boosting brain factors that support nerve growth.
Stepień. Tomasz T; Sacewicz. Małgorzata M; Lawnicka. Hanna H; Krupiński. Roman R;...
The study found that the hormone GHRH, which sermorelin mimics, can make certain lung neuroendocrine tumor cells grow faster and release more factors that promote blood vessel formation and tumor activity. This suggests that using GHRH‑like peptides could potentially stimulate tumor growth in susceptible tissues, so caution is advised for anyone considering them for anti‑aging or performance purposes.
Barabutis. N N; Schally. A V AV
The study shows that the natural hormone GHRH (the same thing sermorelin mimics) can make certain cancer cells grow faster, while blocking GHRH stops them from multiplying. When the cells' own GHRH production was turned off, they stopped growing, but adding back a lab‑made GHRH peptide made them grow again. This suggests that GHRH acts like a growth‑promoting signal for some tumors.
Muñoz-Moreno. Laura L; Carmena. M José MJ; Prieto. Juan C JC; Schally. Andrew V AV; Bajo....
A study found that the hormone‑releasing peptide GHRH (the same family as sermorelin) can make normal prostate cells act more like cancer cells, boosting their growth, movement, and ability to form tumors in mice. This suggests that using GHRH‑type peptides might carry a prostate‑cancer risk, especially with prolonged or high‑dose use.
Barabutis. Nektarios N
The study shows that the brain hormone GHRH, which normally triggers growth hormone release, also affects cell stress pathways and helps keep lung blood vessels intact by boosting a protective protein called P53. Blocking GHRH with antagonists reduced inflammation and could protect against severe lung damage like ARDS, but the work is still early and not a ready‑to‑use treatment for everyday health hacking.
Thounaojam. Menaka C MC; Powell. Folami L FL; Patel. Sagar S; Gutsaeva. Diana R DR; Tawfik. Amany A;...
In diabetic rats, a drug that mimics the hormone that tells the body to release growth hormone (called a GHRH agonist, specifically MR-409) helped protect the eye's retina from damage caused by high blood sugar. It kept retinal cells alive, reduced inflammation and oxidative stress, and lowered leakiness of blood vessels. The opposite drug (a GHRH blocker) made the eye damage worse.
Siejka. Agnieszka A; Schally. Andrew V AV; Block. Norman L NL; Barabutis. Nektarios N
The study shows that the hormone that normally tells the pituitary to release growth hormone (GHRH) can also act like a growth signal for prostate cells that cause benign enlargement (BPH). When researchers blocked GHRH with special antagonist molecules, the prostate cells stopped growing. This suggests that boosting GHRH (as some supplements do) might unintentionally promote prostate growth, while blocking it could be a new way to treat BPH.