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Tesamorelin

Egrifta, TH9507

Quick Stats
Studies 64
Trials 24
Completed PHASE2 INTERVENTIONAL NCT03375788

Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Nonalcoholic fatty liver disease (NAFLD) is common in individuals with obesity and is a significant threat to public health, because it can lead to impaired liver function and liver failure. Growth hormone is a hormone produced in the pituitary gland that helps regulate metabolism and growth. Individuals with obesity, on average, secrete less growth hormone than individuals without obesity. There are data to suggest that growth hormone may help to reduce the amount of fat in the liver, and may also reduce inflammation in the liver, both of which would be helpful to individuals with NAFLD. The purpose of this study is to investigate whether treatment with a drug called tesamorelin, which is a growth hormone releasing hormone analogue, will decrease liver fat and improve liver inflammation and scarring in obese individuals with NAFLD.

Interventions

Name: Tesamorelin
Type: DRUG
Description: Tesamorelin F4 formulation 1.4mg daily
Name: Identical Placebo
Type: DRUG
Description: Placebo injection daily

Primary Outcomes

Measure: Liver Fat Content
TimeFrame: change from baseline to 12 months
Description: Liver Fat Content as measured by hydrogen-magnetic resonance spectroscopy. All available data used; data not available for 1 participant in tesamorelin group and 3 participants in placebo group.

Trial Information

NCT ID

NCT03375788

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE2

Sponsor

Massachusetts General Hospital

Last Updated

December 15, 2025

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